A human monoclonal antibody blocking SARS-CoV-2 infection
A human monoclonal antibody blocking SARS-CoV-2 infection
Abstract The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV). This cross-neutralizing antibody targets a communal epitope on these viruses and offers potential for prevention and treatment of COVID-19.
Wang Chunyan、Okba Nisreen M.A.、Drabek Dubravka、Osterhaus Albert D.M.E.、Haagmans Bart L.、Grosveld Frank、Bosch Berend-Jan、van Kuppeveld Frank J.M.、Li Wentao、van Haperen Rien
Virology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityDepartment of Molecular and Cell Biology, Department of Viroscience, Erasmus Medical CenterDepartment of Cell Biology, Erasmus MC||Harbour Antibodies B.V.University of Veterinary MedicineDepartment of Molecular and Cell Biology, Department of Viroscience, Erasmus Medical CenterDepartment of Cell Biology, Erasmus MC||Harbour Antibodies B.V.Virology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityVirology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityVirology Division, Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht UniversityDepartment of Cell Biology, Erasmus MC||Harbour Antibodies B.V.
医药卫生理论医学研究方法基础医学
Wang Chunyan,Okba Nisreen M.A.,Drabek Dubravka,Osterhaus Albert D.M.E.,Haagmans Bart L.,Grosveld Frank,Bosch Berend-Jan,van Kuppeveld Frank J.M.,Li Wentao,van Haperen Rien.A human monoclonal antibody blocking SARS-CoV-2 infection[EB/OL].(2025-03-28)[2025-05-09].https://www.biorxiv.org/content/10.1101/2020.03.11.987958.点此复制
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