The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities
The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities
Abstract Dislocation in hindlimb tarsals are being observed at a low, but persistent frequency in adult male mice from C57BL/6N substrains. Clinical signs included a sudden onset of mild to severe unilateral or bilateral tarsal abduction, swelling, abnormal hindlimb morphology and lameness. Contraction of digits and gait abnormalities were noted in multiple cases. Radiographical and histological examination revealed caudal dislocation of the calcaneus and partial dislocation of the calcaneoquartal (calcaneous-tarsal bone IV) joint. The detection, frequency, and cause of this pathology in five large mouse production and phenotyping centres (MRC Harwell, UK; The Jackson Laboratory, USA; The Centre for Phenogenomics, Canada; German Mouse Clinic, Germany; Baylor College of Medicine, USA) are discussed.
Hutchison Marie、Flenniken Ann M.、Nutter Lauryl M. J.、Kick Brenda、Doty Rosalinda、Scudamore Cheryl L、White Jacqueline K.、Qu Dawei、Aguilar-Pimentel Juan Antonio、McKerlie Colin、Lyons Bonnie、Seavitt John、Wiegand Jean-Paul、Dickinson Mary、Hrabe de Angelis Martin、Wells Sara、Herbert Eleanor、Hobson Liane、Stewart Michelle
Mary Lyon Centre, MRC Harwell InstituteThe Centre for Phenogenomics||Lunenfeld-Tanenbaum Research Institute, Sinai Health, 600 University AvenueThe Centre for Phenogenomics||The Hospital for Sick Children, 555 University AvenueThe Jackson LaboratoryThe Jackson LaboratoryMary Lyon Centre, MRC Harwell InstituteThe Jackson LaboratoryThe Centre for Phenogenomics||Lunenfeld-Tanenbaum Research Institute, Sinai Health, 600 University AvenueGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum M¨1nchenThe Centre for Phenogenomics||The Hospital for Sick Children, 555 University AvenueThe Jackson LaboratoryBaylor College of MedicineThe Jackson LaboratoryBaylor College of MedicineGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum M¨1nchen||School of Life Science Weihenstephan, Technische Universit?t M¨1nchen||German Center for Diabetes Research (DZD)Mary Lyon Centre, MRC Harwell InstituteDepartment of Pathobiology and Population Sciences, Royal Veterinary CollegeMary Lyon Centre, MRC Harwell InstituteMary Lyon Centre, MRC Harwell Institute
基础医学动物学遗传学
Hutchison Marie,Flenniken Ann M.,Nutter Lauryl M. J.,Kick Brenda,Doty Rosalinda,Scudamore Cheryl L,White Jacqueline K.,Qu Dawei,Aguilar-Pimentel Juan Antonio,McKerlie Colin,Lyons Bonnie,Seavitt John,Wiegand Jean-Paul,Dickinson Mary,Hrabe de Angelis Martin,Wells Sara,Herbert Eleanor,Hobson Liane,Stewart Michelle.The occurrence of tarsal injuries in male mice of C57BL/6N substrains in multiple international mouse facilities[EB/OL].(2025-03-28)[2025-04-27].https://www.biorxiv.org/content/10.1101/2020.02.25.964254.点此复制
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