Pathway centered analysis to guide clinical decision-making in precision medicine
Pathway centered analysis to guide clinical decision-making in precision medicine
Abstract Changes in the human proteome caused by disease before, during and after medical care is phenotype-dependent, so the proteome of each individual at any time point is a snapshot of the body’s response to disease and to disease treatment. Here, we introduce a new concept named differential Personal Pathway index (dPPi). This tool extracts and summates comprehensive disease-specific information contained within an individual’s proteome as a holistic way to follow the response to disease and medical care over time. We demonstrate the principle of the dPPi algorithm on proteins found in urine from patients suffering from neoplasia of the bladder. The relevance of the dPPi results to the individual clinical cases is described. The dPPi concept can be extended to other malignant and non-malignant diseases, and to other types of biopsies, such as plasma, serum or saliva. We envision the dPPi as a tool for clinical decision-making in precision medicine.
Medeiros Mariana、Capelo J. L.、Dhir Rajiv、Lodeiro Carlos、Pinheiro Luis Campos、Santos Hugo M.、Carvalho Lu¨as B.
Urology Department, Central Lisbon Hospital Center||NOVA Medical School. NOVA University of LisbonBIOSCOPE Research Group, LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa||PROTEOMASS Scientific Society, Madan Parque, Rua dos InventoresDepartment of Pathology, University of Pittsburgh Medical CenterBIOSCOPE Research Group, LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa||PROTEOMASS Scientific Society, Madan Parque, Rua dos InventoresUrology Department, Central Lisbon Hospital Center||NOVA Medical School. NOVA University of LisbonBIOSCOPE Research Group, LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa||PROTEOMASS Scientific Society, Madan Parque, Rua dos Inventores||Department of Pathology, University of Pittsburgh Medical CenterBIOSCOPE Research Group, LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa||PROTEOMASS Scientific Society, Madan Parque, Rua dos Inventores
医学研究方法基础医学肿瘤学
Medeiros Mariana,Capelo J. L.,Dhir Rajiv,Lodeiro Carlos,Pinheiro Luis Campos,Santos Hugo M.,Carvalho Lu¨as B..Pathway centered analysis to guide clinical decision-making in precision medicine[EB/OL].(2025-03-28)[2025-04-30].https://www.biorxiv.org/content/10.1101/2021.04.30.442131.点此复制
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