Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community
Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community
Abstract To investigate prevalence of ongoing activation of inflammation following asymptomatic SARS-CoV-2 infection we characterized immune cell transcriptomes from 43 asymptomatic seropositive and 52 highly exposed seronegative individuals with few underlying health issues following a community superspreading event. Four mildly symptomatic seropositive individuals examined three weeks after infection as positive controls demonstrated immunological activation. Approximately four to six weeks following the event, the two asymptomatic groups showed no significant differences. Two seropositive patients with underlying genetic disease impacting immunological activation were included (Cystic Fibrosis (CF), Nuclear factor-kappa B Essential Modulator (NEMO) deficiency). CF, but not NEMO, associated with significant immune transcriptome differences including some associated with severe SARS-CoV-2 infection (IL1B, IL17A, respective receptors). All subjects remained in their usual state of health from event through five-month follow-up. Here, asymptomatic infection resolved without evidence of prolonged immunological activation. Inclusion of subjects with underlying genetic disease illustrated the pathophysiological importance of context on impact of immunological response.
Volland Andre、Bellmann Romuald、Lee Hye Kyung、Knabl Ludwig、Laer Dorothee von、Walser Andreas、Bernhard Christina、Smith Harold E.、Str?hle Mathias、Kang Keunsoo、Furth Priscilla A.、Ludwig Knabl Sr.、G?nzer Hannes、Hennighausen Lothar、Pipperger Lisa、Kaiser Norbert
Institute of Virology, Department of Hygiene, Medical Microbiology and Public Health, Medical University of InnsbruckMedical University InnsbruckNational Institute of Diabetes, Digestive and Kidney DiseasesInstitute of Virology, Department of Hygiene, Medical Microbiology and Public Health, Medical University of InnsbruckInstitute of Virology, Department of Hygiene, Medical Microbiology and Public Health, Medical University of InnsbruckOrdination (Private Practice)Hospital KufsteinNational Institute of Diabetes, Digestive and Kidney DiseasesIntensive Care, Medical University of InnsbruckDankook UniversityDepartments of Oncology & Medicine, Georgetown UniversityKrankenhaus St.Vinzenz ZamsBezirkskrankenhaus SchwazNational Institute of Diabetes, Digestive and Kidney DiseasesInstitute of Virology, Department of Hygiene, Medical Microbiology and Public Health, Medical University of InnsbruckBezirkskrankenhaus St. Johann in Tirol
医学研究方法基础医学
Volland Andre,Bellmann Romuald,Lee Hye Kyung,Knabl Ludwig,Laer Dorothee von,Walser Andreas,Bernhard Christina,Smith Harold E.,Str?hle Mathias,Kang Keunsoo,Furth Priscilla A.,Ludwig Knabl Sr.,G?nzer Hannes,Hennighausen Lothar,Pipperger Lisa,Kaiser Norbert.Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community[EB/OL].(2025-03-28)[2025-06-09].https://www.medrxiv.org/content/10.1101/2020.09.01.20185884.点此复制
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