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粪菌移植对于抑郁症治疗的研究进展

Research progress of fecal bacteria transplantation in the treatment of depression

中文摘要英文摘要

粪菌移植(Fecal Microbiota Transplantation, FMT)作为一种调节菌群失调的医疗方法近年来受到广泛关注,其核心步骤包括从健康捐赠者粪便中提取功能菌群,并通过相关医疗技术将其安全、有效地移植到患者的胃肠道内,以达到重建肠道菌群的平衡,进而实现相关疾病的治疗。其中,在抗抑郁症方面的应用及其潜力已逐渐获得科学验证,展现出显著的可行性和有效性,为抑郁症的治疗提供了新的视角和策略。本文旨在总结肠道菌群与抑郁症之间的相互关系,通过对FMT抗抑郁的基础和临床研究,探讨其可能的起效机制、临床疗效及一些不足与发展前景,以期为后续抑郁症的临床治疗提供参考和帮助。

In recent years, Fecal Microbiota Transplantation (FMT) has attracted wide attention as a medical method to regulate flora disorders. The core steps of FMT include extracting functional flora from the feces of healthy donors and transplanting it safely and effectively into the gastrointestinal tract of patients through relevant medical techniques. In order to rebuild the balance of intestinal flora, and then realize the treatment of related diseases. Among them, the application and its potential in anti-depression has gradually been scientifically verified, showing significant feasibility and effectiveness, providing a new perspective and strategy for the treatment of depression. This paper aims to summarize the relationship between intestinal flora and depression, and explore its possible mechanism of action, clinical efficacy, deficiencies and development prospects through the basic and clinical research on FMT antidepressant, in order to provide reference and help for the subsequent clinical treatment of depression.

吴亚楠、赵帆、唐宗康、吴亚平、朱国辉

10.12201/bmr.202408.00043

神经病学、精神病学基础医学微生物学

粪菌移植抑郁症肠道菌群微生物—肠—脑轴

Fecal bacteria transplantationepressionIntestinal floraMicrobiome - gut - brain axis

吴亚楠,赵帆,唐宗康,吴亚平,朱国辉.粪菌移植对于抑郁症治疗的研究进展[EB/OL].(2024-07-07)[2025-08-03].https://www.biomedrxiv.org.cn/article/doi/bmr.202408.00043.点此复制

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