Decomposing variation in immune response in a wild rodent population
Decomposing variation in immune response in a wild rodent population
Abstract Individuals vary in their immune response and, as a result, some are more susceptible to infectious disease than others. Little is known about which components of immune pathways are responsible for this variation, but understanding these underlying processes could allow us to predict the outcome of infection for an individual, and to manage their health more effectively. In this study, we describe transcriptome-wide variation in immune response (to a standardised challenge) in a wild population of field voles (Microtus agrestis). We find that this variation can be categorised into three main types. We also identify markers, across these three categories, which display particularly strong individual variation in response. This work shows how a simple standardised challenge performed on a natural population can reveal complex patterns of natural variation in immune response.
Wanelik Klara M.、Arriero Elena、Bradley Janette E.、Friberg Ida M.、Paterson Steve、Begon Mike、Jackson Joseph A.、Taylor Christopher H.
Institute of Integrative Biology, University of LiverpoolSchool of Life Sciences, University of Nottingham||Department of Biodiversity, Ecology and Evolution, University Complutense of MadridSchool of Life Sciences, University of NottinghamSchool of Environment and Life Sciences, University of SalfordInstitute of Integrative Biology, University of LiverpoolInstitute of Integrative Biology, University of LiverpoolSchool of Environment and Life Sciences, University of SalfordSchool of Life Sciences, University of Nottingham
生物科学现状、生物科学发展生物科学研究方法、生物科学研究技术动物学
Wanelik Klara M.,Arriero Elena,Bradley Janette E.,Friberg Ida M.,Paterson Steve,Begon Mike,Jackson Joseph A.,Taylor Christopher H..Decomposing variation in immune response in a wild rodent population[EB/OL].(2025-03-28)[2025-05-08].https://www.biorxiv.org/content/10.1101/622225.点此复制
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