Optimal maturation of the SIV-specific CD8 + T-cell response after primary infection is associated with natural control of SIV. ANRS SIC study
Optimal maturation of the SIV-specific CD8 + T-cell response after primary infection is associated with natural control of SIV. ANRS SIC study
ABSTRACT Highly efficient virus-specific CD8+ T-cells are associated with immune control of HIV infection, but it remains unclear how these cells are generated and maintained over time. We used a macaque model of spontaneous control of SIVmac251 infection to monitor the development and evolution of potent antiviral CD8+ T-cell responses. SIV-specific CD8+ T-cells emerged during primary infection in all animals. However, the ability of CD8+ T cells to suppress SIV replication was low in early stages but increased after a period of maturation, temporally linked with the establishment of sustained low-level viremia in controller macaques. SIV-specific CD8+ T-cells with a central memory phenotype expressed higher levels of survival markers in controllers versus non-controllers. In contrast, a persistently skewed differentiation phenotype was observed among central memory SIV-specific CD8+ T-cells in non-controllers since primary infection, typified by relatively high expression levels of T-bet. Collectively, these data show that the phenotype of SIV-specific CD8+ T-cells defined early after SIV infection favor the gain of antiviral potency as a function of time in controllers, whereas SIV-specific CD8+ T-cell responses in non-controllers fail to gain antiviral potency due to early defects imprinted in the central memory pool.
Guedj Jeremie、Sylla Naya、Passaes Caroline、Madelain Vincent、David Annie、Grand Roger Le、M¨1ller-Trutwin Michaela、Rouzioux Christine、S¨￠ez-Ciri¨?n Asier、Lambotte Olivier、Versmisse Pierre、Gostick Emma、Vaslin Bruno、Monceaux Val¨|rie、Avettand-Fenoel Veronique、Blancher Antoine、Price David A.、Millet Antoine、Dereuddre-Bosquet Nathalie、Pancino Gianfranco
IAME, UMR 1137, INSERM, Universit¨| Paris DiderotCEA-Universit¨| Paris Sud-INSERM, UMR1184 ??Immunology of Viral Infections and Autoimmune Diseases?ˉ-IDMIT DepartmentInstitut Pasteur, HIV Inflammation and Persistence||CEA-Universit¨| Paris Sud-INSERM, UMR1184 ??Immunology of Viral Infections and Autoimmune Diseases?ˉ-IDMIT DepartmentIAME, UMR 1137, INSERM, Universit¨| Paris DiderotInstitut Pasteur, HIV Inflammation and PersistenceCEA-Universit¨| Paris Sud-INSERM, UMR1184 ??Immunology of Viral Infections and Autoimmune Diseases?ˉ-IDMIT DepartmentInstitut Pasteur, HIV Inflammation and PersistenceUniversit¨| Paris-Descartes||Assistance Publique-H?pitaux de Paris, Service de Microbiologie Clinique, H?pital Necker-Enfants MaladesInstitut Pasteur, HIV Inflammation and PersistenceCEA-Universit¨| Paris Sud-INSERM, UMR1184 ??Immunology of Viral Infections and Autoimmune Diseases?ˉ-IDMIT Department||Assistance Publique-H?pitaux de Paris, Service de M¨|decine Interne et Immunologie Clinique, Groupe Hospitalier Universitaire Paris Sud, H?pital Bic¨otreInstitut Pasteur, HIV Inflammation and PersistenceCardiff University School of Medicine, Division of Infection and ImmunityCEA-Universit¨| Paris Sud-INSERM, UMR1184 ??Immunology of Viral Infections and Autoimmune Diseases?ˉ-IDMIT DepartmentInstitut Pasteur, HIV Inflammation and PersistenceUniversit¨| Paris-Descartes||Assistance Publique-H?pitaux de Paris, Service de Microbiologie Clinique, H?pital Necker-Enfants MaladesLaboratoire d?ˉImmunog¨|n¨|tique Mol¨|culaire||Laboratoire d?ˉImmunologie, CHU de ToulouseCardiff University School of Medicine, Division of Infection and ImmunityUniversit¨| Paris-DescartesCEA-Universit¨| Paris Sud-INSERM, UMR1184 ??Immunology of Viral Infections and Autoimmune Diseases?ˉ-IDMIT DepartmentInstitut Pasteur, HIV Inflammation and Persistence
基础医学
Guedj Jeremie,Sylla Naya,Passaes Caroline,Madelain Vincent,David Annie,Grand Roger Le,M¨1ller-Trutwin Michaela,Rouzioux Christine,S¨￠ez-Ciri¨?n Asier,Lambotte Olivier,Versmisse Pierre,Gostick Emma,Vaslin Bruno,Monceaux Val¨|rie,Avettand-Fenoel Veronique,Blancher Antoine,Price David A.,Millet Antoine,Dereuddre-Bosquet Nathalie,Pancino Gianfranco.Optimal maturation of the SIV-specific CD8 + T-cell response after primary infection is associated with natural control of SIV. ANRS SIC study[EB/OL].(2025-03-28)[2025-05-11].https://www.biorxiv.org/content/10.1101/2019.12.20.885459.点此复制
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