Targeting lateral inhibition to improve vision following macular degeneration
Targeting lateral inhibition to improve vision following macular degeneration
Abstract Macular degeneration is the leading cause of blindness in the developed world. Whilst most patients lose sight owing to atrophic changes, no treatments currently exist that improve the vision deficit due to atrophy. Here, we identify loss of lateral inhibition as a specific mechanism by which photoreceptor degeneration reduces visual function beyond the atrophic area. We find that this inhibition is adaptive, and that if modulated can improve visual function, making inhibitory circuits an unexpected therapeutic target for age related macular degeneration and related disorders.
Jones PR、Robinson MR、Matsuki T、Georgiadis A、Georgiou M、Ripamonti C、Michaelides M、Rubin GS、Maswood RN、Rizzi M、Ali RR、Smith AJ、Powell K、Hoke J
UCL Institute of OphthalmologyUCL Institute of OphthalmologyUCL Institute of OphthalmologyUCL Institute of OphthalmologyUCL Institute of OphthalmologyCRS Ltd. RochesterUCL Institute of OphthalmologyUCL Institute of OphthalmologyUCL Institute of OphthalmologyUCL Institute of OphthalmologyUCL Institute of Ophthalmology||NIHR Biomedical Research Centre at Moorfields Eye Hospital and UCL Institute of OphthalmologyUCL Institute of OphthalmologyUCL Institute of OphthalmologyUCL Institute of Ophthalmology
眼科学基础医学医学研究方法
Jones PR,Robinson MR,Matsuki T,Georgiadis A,Georgiou M,Ripamonti C,Michaelides M,Rubin GS,Maswood RN,Rizzi M,Ali RR,Smith AJ,Powell K,Hoke J.Targeting lateral inhibition to improve vision following macular degeneration[EB/OL].(2025-03-28)[2025-06-15].https://www.biorxiv.org/content/10.1101/2020.02.21.953828.点此复制
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