Stimulus novelty uncovers coding diversity in visual cortical circuits
Stimulus novelty uncovers coding diversity in visual cortical circuits
The detection of novel stimuli is critical to learn and survive in a dynamic environment. Though novel stimuli powerfully affect brain activity, their impact on specific cell types and circuits is not well understood. Disinhibition is one candidate mechanism for novelty-induced enhancements in activity. Here we characterize the impact of stimulus novelty on disinhibitory circuit components using longitudinal 2-photon calcium imaging of Vip, Sst, and excitatory populations in the mouse visual cortex. Mice learn a behavioral task with stimuli that become highly familiar, then are tested on both familiar and novel stimuli. Mice consistently perform the task with novel stimuli, yet responses to stimulus presentations and stimulus omissions are dramatically altered. Further, we find that novelty modifies coding of visual as well as behavioral and task information. At the population level, the direction of these changes is consistent with engagement of the Vip-Sst disinhibitory circuit. At the single cell level, we identify separate clusters of Vip, Sst, and excitatory cells with unique patterns of novelty-induced coding changes. This study and the accompanying open-access dataset reveals the impact of novelty on sensory and behavioral representations in visual cortical circuits and establishes novelty as a key driver of cellular functional diversity.
Bowman Chris、Departee Max、Mace Kyla、Kivikas Sara、Ledochowitsch Peter、Mochizuki Chris、Ng Lydia、Oliver Michael、Rhoads Paul、Schelonka Kathryn、Sevigny Josh、Sullivan David、Sutton Ben、Koch Christof、Wang Michael、Farrell Colin、Mihalas Stefan、Olsen Shawn R、Ollerenshaw Doug、Najafi Farzaneh、Caldejon Shiella、Casal Linzy、Kapner Daniel、Manavi Sahar、Mei Nicholas、Morrison Christopher B.、Ponvert Nick、Roll Clark、Ahmed Ruweida、Amine Daniel、Billeh Yazan、Cain Nicholas、Cho Andrew、Gradis Nile、Grasso Conor、Kato India、Phillips John、Naylor Sarah、Liang Elizabeth、North Katherine、Piet Alex、Hancock Nicole、Nayan Chelsea、Hu Brian、Waughman Xana、Williford Allison、Nguyen Thuyanh K、Perkins Jed、Arkhipov Anton、D'Orazi Florence、Buice Michael、Desoto Marie、Ronellenfitch Kara、Swapp Jackie、Zeng Hongkui、Lambert Sophie、Leon Arielle、Ocker Gabriel Koch、Seid Sam、Bennett Corbett、Kiggins Justin、Lecoq Jerome、Kuan Leonard、Jia Xiaoxuan、Wakeman Wayne、Daniel Scott、Johnson Tye、Hytnen Ross、Garrett Marina、de Vries Saskia EJ、Groblewski Peter、Gale Sam、Orlova Natalia、Gelfand Emily、L'Heureux Quinn、Amster Adam、Dawe Tim、Williams Derric、Long Fuhui、Yavorska Iryna、Magrans de Abril Ildefons、Feng David、Wilkes Joshua
生物物理学生理学细胞生物学
Bowman Chris,Departee Max,Mace Kyla,Kivikas Sara,Ledochowitsch Peter,Mochizuki Chris,Ng Lydia,Oliver Michael,Rhoads Paul,Schelonka Kathryn,Sevigny Josh,Sullivan David,Sutton Ben,Koch Christof,Wang Michael,Farrell Colin,Mihalas Stefan,Olsen Shawn R,Ollerenshaw Doug,Najafi Farzaneh,Caldejon Shiella,Casal Linzy,Kapner Daniel,Manavi Sahar,Mei Nicholas,Morrison Christopher B.,Ponvert Nick,Roll Clark,Ahmed Ruweida,Amine Daniel,Billeh Yazan,Cain Nicholas,Cho Andrew,Gradis Nile,Grasso Conor,Kato India,Phillips John,Naylor Sarah,Liang Elizabeth,North Katherine,Piet Alex,Hancock Nicole,Nayan Chelsea,Hu Brian,Waughman Xana,Williford Allison,Nguyen Thuyanh K,Perkins Jed,Arkhipov Anton,D'Orazi Florence,Buice Michael,Desoto Marie,Ronellenfitch Kara,Swapp Jackie,Zeng Hongkui,Lambert Sophie,Leon Arielle,Ocker Gabriel Koch,Seid Sam,Bennett Corbett,Kiggins Justin,Lecoq Jerome,Kuan Leonard,Jia Xiaoxuan,Wakeman Wayne,Daniel Scott,Johnson Tye,Hytnen Ross,Garrett Marina,de Vries Saskia EJ,Groblewski Peter,Gale Sam,Orlova Natalia,Gelfand Emily,L'Heureux Quinn,Amster Adam,Dawe Tim,Williams Derric,Long Fuhui,Yavorska Iryna,Magrans de Abril Ildefons,Feng David,Wilkes Joshua.Stimulus novelty uncovers coding diversity in visual cortical circuits[EB/OL].(2025-03-28)[2025-05-09].https://www.biorxiv.org/content/10.1101/2023.02.14.528085.点此复制
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