The Clinical Significance and Biological Function of DPEP1 in B-cell Acute Lymphoblastic Leukemia
The Clinical Significance and Biological Function of DPEP1 in B-cell Acute Lymphoblastic Leukemia
Abstract Dehydropeptidase-1 (DPEP1) is a zinc-dependent metalloproteinase abnormally expressed in many cancers. However, its potential role in adults with B-cell acute lymphoblastic leukaemia (ALL) is unknown. We found that in adults with common-B-cell ALL high DPEP1 transcript levels at diagnosis was independently-associated with an increased CIR and worse RFS compared with subjects with low transcript levels. We show an increased proliferation and pro-survival role of DPEP1 in B-cell ALL cells via regulation of phosphCREB and p53 which may be the biological basis of the clinical correlation we report. Our data implicate DPEP1 expression in the biology of common B-cell ALL in adults. We report clinical correlates and provide a potential biological basis for these correlations. If confirmed, analyzing DPEP1 transcript levels at diagnosis could help predict therapy-outcomes. Moreover, regulation of DPEP1 expression could be a therapy target in B-cell ALL.
Wu Li-Xin、Xu Yan、Jiang Hao、Liu Kai-Yan、Ruan Guo-Rui、Jiang Bin、Liu Yan-Rong、Zhang Jia-Min、Qin Ya-Zhen、Zhang Jing、Wang Yu、Chen Yu-Hong、Huang Xiao-Jun、Feng Yong-Huai、Xu Lan-Ping、Gale Robert Peter、Jiang Qian、Zhang Xiao-Hui
Peking University Peoples Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation and Collaborative Innovation Center of Hematology, Peking UniversityPeking University Peoples Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation and Collaborative Innovation Center of Hematology, Peking UniversityPeking University Peoples Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation and Collaborative Innovation Center of Hematology, Peking UniversityPeking University Peoples Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation and Collaborative Innovation Center of Hematology, Peking UniversityPeking University Peoples Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation and Collaborative Innovation Center of Hematology, Peking UniversityPeking University Peoples Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation and Collaborative Innovation Center of Hematology, Peking UniversityPeking University Peoples Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation and Collaborative Innovation Center of Hematology, Peking UniversityPeking University Peoples Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation and Collaborative Innovation Center of Hematology, Peking UniversityPeking University Peoples Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation and Collaborative Innovation Center of Hematology, Peking UniversityPeking University Peoples Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation and Collaborative Innovation Center of Hematology, Peking UniversityPeking University Peoples Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation and Collaborative Innovation Center of Hematology, Peking UniversityPeking University Peoples Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation and Collaborative Innovation Center of Hematology, Peking UniversityPeking University Peoples Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation and Collaborative Innovation Center of Hematology, Peking UniversityPeking University Peoples Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation and Collaborative Innovation Center of Hematology, Peking UniversityHaematology Research Center, Division of Experimental Medicine, Department of Medicine, Imperial College LondonPeking University Peoples Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation and Collaborative Innovation Center of Hematology, Peking UniversityPeking University Peoples Hospital, Peking University Institute of Hematology, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation and Collaborative Innovation Center of Hematology, Peking University
肿瘤学基础医学临床医学
Wu Li-Xin,Xu Yan,Jiang Hao,Liu Kai-Yan,Ruan Guo-Rui,Jiang Bin,Liu Yan-Rong,Zhang Jia-Min,Qin Ya-Zhen,Zhang Jing,Wang Yu,Chen Yu-Hong,Huang Xiao-Jun,Feng Yong-Huai,Xu Lan-Ping,Gale Robert Peter,Jiang Qian,Zhang Xiao-Hui.The Clinical Significance and Biological Function of DPEP1 in B-cell Acute Lymphoblastic Leukemia[EB/OL].(2025-03-28)[2025-06-25].https://www.biorxiv.org/content/10.1101/742551.点此复制
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