Negative correlation between the expression of tlr4 and grp78 is characteristic of sepsis onset and progression
Negative correlation between the expression of tlr4 and grp78 is characteristic of sepsis onset and progression
Abstract In sepsis caused by Gram-negative bacteria, modulation of Toll-like receptor 4 (TLR4) activity by modulators such as glucose-regulated protein 78 kDa (GRP78), is believed to shift the equilibrium between pro- and anti-inflammatory downstream signaling cascade. We measured daily mRNA tlr4 and grp78 expression levels in peripheral blood of a cohort of septic patients, upon intensive care admission, and modeled these mRNA values based on a sine damping function. We obtained negative correlations between tlr4 and grp78 mRNA in the survivor group. In contrast, such relation is lost in the deceased patients. Effect sizes were 2.035 (tlr4) and 2.168 (grp78). Measuring the correlation patterns of the expression of these two genes may serve as a robust means to gauge sepsis progression, requiring three points of measurement on the first day of hospitalization. Higher levels of grp78 and lower levels of tlr4 anticipated a positive evolution of sepsis, resulting in patient survival.
Stan Razvan C.、Bonin Camila P.、Porto Rose、de Camargo Maristela M.、Soriano Francisco G.
Laboratory of Molecular Immunoregulation, Institute of Biomedical Sciences, University of S?o PauloLaboratory of Molecular Immunoregulation, Institute of Biomedical Sciences, University of S?o PauloUniversity Hospital, University of Sao PauloLaboratory of Molecular Immunoregulation, Institute of Biomedical Sciences, University of S?o PauloUniversity Hospital, University of Sao Paulo||School of Medicine, University of Sao Paulo
基础医学医学研究方法
Stan Razvan C.,Bonin Camila P.,Porto Rose,de Camargo Maristela M.,Soriano Francisco G..Negative correlation between the expression of tlr4 and grp78 is characteristic of sepsis onset and progression[EB/OL].(2025-03-28)[2025-05-14].https://www.biorxiv.org/content/10.1101/133264.点此复制
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