Mid-lateral Cerebellar Purkinje Cells Provide a Cognitive Error Signal When Monkeys Learn a New Visuomotor Association
Mid-lateral Cerebellar Purkinje Cells Provide a Cognitive Error Signal When Monkeys Learn a New Visuomotor Association
Abstract How do we learn to establish associations between arbitrary visual cues (like a red light) and movements (like braking the car)? We investigated the neural correlates of visuomotor association learning in the monkey mid-lateral cerebellum. Here we show that, during learning but not when the associations were overlearned, individual Purkinje cells reported the outcome of the monkey’s most recent decision, an error signal, which was independent of changes in hand movement or reaction time. At the population level, Purkinje cells collectively maintained a memory of the most recent decision throughout the entire trial period, updating it after every decision. This error signal decreased as the performance improved. Our results suggest a role of mid-lateral cerebellum in visuomotor associative learning and provide evidence that cerebellum could be a generalized learning system, essential in non-motor learning as well as motor learning.
Ipata Anna E.、Goldberg Michael E.、Sendhilnathan Naveen
Dept. of Neuroscience, Mahoney Center for Brain and Behavior Research, Columbia University||New York State Psychiatric InstituteDept. of Neuroscience, Mahoney Center for Brain and Behavior Research, Columbia University||Zuckerman Mind, Brain, and Behavior Institute, Columbia University||New York State Psychiatric Institute||Kavli Institute for Brain Science, Columbia University||Dept. of Neurology, Psychiatry, and Ophthalmology, Columbia University College of Physicians and SurgeonsDoctoral program in Neurobiology and Behavior, Columbia University||Dept. of Neuroscience, Mahoney Center for Brain and Behavior Research, Columbia University||Zuckerman Mind, Brain, and Behavior Institute, Columbia University||New York State Psychiatric Institute
生物科学现状、生物科学发展生物科学研究方法、生物科学研究技术生理学
Ipata Anna E.,Goldberg Michael E.,Sendhilnathan Naveen.Mid-lateral Cerebellar Purkinje Cells Provide a Cognitive Error Signal When Monkeys Learn a New Visuomotor Association[EB/OL].(2025-03-28)[2025-05-17].https://www.biorxiv.org/content/10.1101/600221.点此复制
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