Clonal Hematopoiesis of Indeterminate Potential Status is Associated with Left Main Artery Stenosis
Clonal Hematopoiesis of Indeterminate Potential Status is Associated with Left Main Artery Stenosis
Abstract Clonal hematopoiesis of indeterminate potential (CHIP) occurs as a result of acquired mutations in bone marrow progenitor cells. CHIP confers a twofold risk of atherosclerotic cardiovascular disease (ASCVD). However, there is limited data regarding specific cardiovascular phenotypes in this population. We recruited patients from the Vanderbilt University Medical Center cardiac catheterization laboratory and performed next generation sequencing to determine CHIP status. Multivariable logistic regression models and proportional odds models were used to assess the association between CHIP status and coronary angiography. We find nearly 1 in 5 patients undergoing coronary angiography have a CHIP mutation. Those with CHIP had a higher risk of having left main coronary artery disease compared to non-CHIP carriers. We additionally find that those with a specific CHIP mutation, ten eleven translocase 2 (TET2) has a larger effect size on left main stenosis compared with other CHIP mutations. This is the first description of a specific atherosclerotic phenotype in CHIP and serves as a basis for understanding enhanced morbidity and mortality in CHIP.
Barker Colin M.、Raddatz Michael A.、Wells John、Vlasschaert Caitlyn、Umbarger Kelsey、Foster Kristoff、Su Yan Ru、Olson Sydney、Bick Alexander G.、Boateng Emmanuel、Heimlich J. Brett、Roden Dan M.、Threadcraft Marcus
Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical CenterDepartment of Medicine, University of California Los AngelesDepartment of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical CenterDepartment of Medicine, Queen?ˉs UniversityDepartment of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical CenterDepartment of Medicine, Vanderbilt University Medical CenterDepartment of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical CenterDepartment of Medicine, Vanderbilt University Medical CenterDepartment of Medicine, Vanderbilt University Medical CenterDepartment of Medicine, Vanderbilt University Medical CenterDepartment of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical CenterDepartment of Medicine, Division of Cardiovascular Medicine, Vanderbilt University Medical Center||Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical CenterDepartment of Medicine, Vanderbilt University Medical Center
医学研究方法临床医学内科学
Barker Colin M.,Raddatz Michael A.,Wells John,Vlasschaert Caitlyn,Umbarger Kelsey,Foster Kristoff,Su Yan Ru,Olson Sydney,Bick Alexander G.,Boateng Emmanuel,Heimlich J. Brett,Roden Dan M.,Threadcraft Marcus.Clonal Hematopoiesis of Indeterminate Potential Status is Associated with Left Main Artery Stenosis[EB/OL].(2025-03-28)[2025-06-16].https://www.medrxiv.org/content/10.1101/2023.02.10.23285708.点此复制
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