Metabolic Reaction Network-based Recursive Metabolite Identification for Untargeted Metabolomics
Metabolic Reaction Network-based Recursive Metabolite Identification for Untargeted Metabolomics
Metabolite identification is a long-standing challenge in untargeted metabolomics and a major hurdle for functional metabolomics studies. Here, we developed a metabolic reaction network-based recursive algorithm and webserver called MetDNA for the large-scale and unambiguous identification of metabolites (available at http://metdna.zhulab.cn). We showcased the versatility of our workflow using different instrument platforms, data acquisition methods, and biological sample types and demonstrated that over 2,000 metabolites could be identified from one experiment.
Ma Zaijun、Wang Ruohong、Zhu Zheng-Jiang、Cai Yuping、Liu Nan、Shen Xiaotao、Yin Yandong、Xiong Xin
Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences||University of Chinese Academy of SciencesInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences||University of Chinese Academy of SciencesInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences||University of Chinese Academy of SciencesInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences||University of Chinese Academy of SciencesInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of SciencesInterdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
生物科学研究方法、生物科学研究技术生物化学
Ma Zaijun,Wang Ruohong,Zhu Zheng-Jiang,Cai Yuping,Liu Nan,Shen Xiaotao,Yin Yandong,Xiong Xin.Metabolic Reaction Network-based Recursive Metabolite Identification for Untargeted Metabolomics[EB/OL].(2025-03-28)[2025-04-26].https://www.biorxiv.org/content/10.1101/305201.点此复制
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