Hippocampal subfield volumes across the healthy lifespan and the effects of MR sequence on estimates
Hippocampal subfield volumes across the healthy lifespan and the effects of MR sequence on estimates
Abstract The hippocampus has been extensively studied in various neuropsychiatric disorders throughout the lifespan. However, inconsistent results have been reported with respect to which subfield volumes are most related to age. Here, we investigate whether these discrepancies may be explained by experimental design differences that exist between studies. Multiple datasets were used to collect 1690 magnetic resonance scans from healthy individuals aged 18-95 years old. Standard T1-weighted (T1w; MPRAGE sequence, 1 mm3 voxels), high-resolution T2-weighted (T2w; SPACE sequence, 0.64 mm3 voxels) and slab T2-weighted (Slab; 2D turbo spin echo, 0.4 x 0.4 x 2 mm3 voxels) images were acquired. The MAGeT Brain algorithm was used for segmentation of the hippocampal grey matter (GM) subfields and peri-hippocampal white matter (WM) subregions. Linear mixed-effect models and Akaike information criterion were used to examine linear, second or third order natural splines relationship between hippocampal volumes and age. We demonstrated that stratum radiatum/lacunosum/moleculare and fornix subregions expressed the highest relative volumetric decrease, while the cornus ammonis 1 presented a relative volumetric preservation of its volume with age. We also found that volumes extracted from slab images were often underestimated and demonstrated different age-related relationships compared to volumes extracted from T1w and T2w images. The current work suggests that although T1w, T2w and slab derived subfield volumetric outputs are largely homologous, modality choice plays a meaningful role in the volumetric estimation of the hippocampal subfields.
Tullo Stephanie、Bedford Saashi A.、B¨|land Marie-Lise、Farzin Sarah、Chakravarty Mallar、Salaciak Alyssa、Patel Raihaan、Bussy Aurelie、Kazazian Christina、Tardif Christine、Devenyi Gabriel A.、Plitman Eric、Valiquette Vanessa
Computional Brain Anatomy (CoBrA) Laboratory, Cerebral Imaging Centre, Douglas Mental Health University Institute||Integrated Program in Neuroscience, McGill UniversityComputional Brain Anatomy (CoBrA) Laboratory, Cerebral Imaging Centre, Douglas Mental Health University Institute||Department of Psychiatry, McGill UniversityComputional Brain Anatomy (CoBrA) Laboratory, Cerebral Imaging Centre, Douglas Mental Health University InstituteComputional Brain Anatomy (CoBrA) Laboratory, Cerebral Imaging Centre, Douglas Mental Health University InstituteComputional Brain Anatomy (CoBrA) Laboratory, Cerebral Imaging Centre, Douglas Mental Health University Institute||Integrated Program in Neuroscience, McGill University||Department of Psychiatry, McGill University||Department of Biomedical Engineering, McGill UniversityComputional Brain Anatomy (CoBrA) Laboratory, Cerebral Imaging Centre, Douglas Mental Health University InstituteComputional Brain Anatomy (CoBrA) Laboratory, Cerebral Imaging Centre, Douglas Mental Health University Institute||Department of Biomedical Engineering, McGill UniversityComputional Brain Anatomy (CoBrA) Laboratory, Cerebral Imaging Centre, Douglas Mental Health University Institute||Integrated Program in Neuroscience, McGill UniversityDepartment of Biomedical Engineering, McGill UniversityDepartment of Biomedical Engineering, McGill University||McConnell Brain Imaging Centre, Montreal Neurological Institute||Department of Neurology and Neurosurgery, McGill UniversityComputional Brain Anatomy (CoBrA) Laboratory, Cerebral Imaging Centre, Douglas Mental Health University Institute||Department of Psychiatry, McGill UniversityComputional Brain Anatomy (CoBrA) Laboratory, Cerebral Imaging Centre, Douglas Mental Health University Institute||Department of Psychiatry, McGill UniversityComputional Brain Anatomy (CoBrA) Laboratory, Cerebral Imaging Centre, Douglas Mental Health University Institute||Department of Biomedical Engineering, McGill University
神经病学、精神病学基础医学医学研究方法
Tullo Stephanie,Bedford Saashi A.,B¨|land Marie-Lise,Farzin Sarah,Chakravarty Mallar,Salaciak Alyssa,Patel Raihaan,Bussy Aurelie,Kazazian Christina,Tardif Christine,Devenyi Gabriel A.,Plitman Eric,Valiquette Vanessa.Hippocampal subfield volumes across the healthy lifespan and the effects of MR sequence on estimates[EB/OL].(2025-03-28)[2025-04-26].https://www.biorxiv.org/content/10.1101/2020.05.28.121343.点此复制
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