Single-cell RNA Expression of SARS-CoV-2 Cell Entry Factors in Human Endometrium during Preconception
Single-cell RNA Expression of SARS-CoV-2 Cell Entry Factors in Human Endometrium during Preconception
Abstract We investigated potential SARS-CoV-2 tropism in human endometrium by single-cell RNA-sequencing of viral entry-associated genes in healthy women. Percentages of endometrial cells expressing ACE2, TMPRSS2, CTSB, or CTSL were <2%, 12%, 80%, and 80%, respectively, with 0.7% of cells expressing all four genes. Our findings imply low efficiency of SARS-CoV-2 infection in the endometrium before embryo implantation, providing information to assess preconception risk in asymptomatic carriers.
Vilella Felipe、Wang Wanxin、Moreno Inmaculada、Simon Carlos、Quake Stephen R.
Igenomix Foundation, INCLIVA Health Research Institute||Department of Obstetrics & Gynecology, Beth Israel Deaconess Medical Center, Harvard UniversityDepartment of Bioengineering, Stanford UniversityIgenomix Foundation, INCLIVA Health Research InstituteIgenomix Foundation, INCLIVA Health Research Institute||Department of Obstetrics & Gynecology, University of Valencia||Department of Obstetrics & Gynecology, Beth Israel Deaconess Medical Center, Harvard UniversityDepartment of Bioengineering, Stanford University||Department of Applied Physics, Stanford University||Chan Zuckerberg Biohub
基础医学细胞生物学分子生物学
Vilella Felipe,Wang Wanxin,Moreno Inmaculada,Simon Carlos,Quake Stephen R..Single-cell RNA Expression of SARS-CoV-2 Cell Entry Factors in Human Endometrium during Preconception[EB/OL].(2025-03-28)[2025-06-20].https://www.biorxiv.org/content/10.1101/2020.09.14.296806.点此复制
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