High-phytate/low-calcium diet is a risk factor for crystal nephropathies, renal phosphate wasting, and bone loss
High-phytate/low-calcium diet is a risk factor for crystal nephropathies, renal phosphate wasting, and bone loss
Phosphate overload contributes to mineral bone disorders associated with crystal nephropathies. Phytate, the major form of phosphorus in plant seeds, is known as an indigestible and negligible in humans. However, the mechanism and adverse effects of high-phytate intake on Ca2+ and phosphate absorption and homeostasis are unknown. Here we show that excessive intake of phytate with a low-Ca2+ diet fed to rats contributed to the development of crystal nephropathies, renal phosphate wasting, and bone loss through tubular dysfunction secondary to dysregulation of intestinal calcium and phosphate absorption. Moreover, Ca2+ supplementation alleviated the detrimental effects of excess dietary phytate on bone and kidney through excretion of undigested Ca2+-phytate, which prevented a vicious cycle of intestinal phosphate overload and renal phosphate wasting while improving intestinal Ca2+ bioavailability. Thus, we demonstrate that phytate is digestible without a high-Ca2+ diet and a risk factor for phosphate overloading and developing crystal nephropathies and bone disease.
Lee Cheol Soon、Park Kyong Soo、Im Seung-Soon、Oh Byung-Chul、Yang Jun-Young、Choi Cheolsoo、Lee Jinwook、Choi Han Seok、Park Young Joo、Lee Young Jae、Kim Jung-Wan、Cha Ji-Young、Auh Joong-Hyuck、Kim Hyeonjin、Hur June、Kang Jinku、Choi Hyung Jin、Booth Carmen J.、Kim Ok-Hee、Cho Sun Wook、Lee Dae Ho、Kim Young-Bum
Medical Health Research Center, Korea University Anam HospitalDepartment of Internal Medicine, Seoul National University College of MedicineDepartment of Physiology, Keimyung University School of MedicineDepartment of Physiology, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of MedicineDepartment of Toxicological Evaluation and Research, Ministry of Food and Drug SafetyDepartment of Internal Medicine, Gachon University Gil Medical CenterDepartment of Physiology, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of MedicineDivision of Endocrinology and Metabolism, Department of Internal Medicine, Dongguk University Ilsan HospitalDepartment of Internal Medicine, Seoul National University College of MedicineDepartment of Biochemistry, Lee Gil Ya Cancer and Diabetes Institute Gachon University College of MedicineDepartment of Biology, University of Incheon 21999Department of Biochemistry, Lee Gil Ya Cancer and Diabetes Institute Gachon University College of MedicineDepartment of Food Science and Technology, Chung-Ang UniversityDepartment of Radiology, Seoul National University College of MedicineDepartment of Physiology, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of MedicineDepartment of Physiology, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of MedicineDepartment of Anatomy, Seoul National University College of MedicineDepartment of Comparative Medicine, Yale University School of MedicineDepartment of Physiology, Lee Gil Ya Cancer and Diabetes Institute, Gachon University College of MedicineDepartment of Internal Medicine, Seoul National University College of MedicineDepartment of Internal Medicine, Gachon University Gil Medical CenterDivision of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School
基础医学生理学生物化学
Lee Cheol Soon,Park Kyong Soo,Im Seung-Soon,Oh Byung-Chul,Yang Jun-Young,Choi Cheolsoo,Lee Jinwook,Choi Han Seok,Park Young Joo,Lee Young Jae,Kim Jung-Wan,Cha Ji-Young,Auh Joong-Hyuck,Kim Hyeonjin,Hur June,Kang Jinku,Choi Hyung Jin,Booth Carmen J.,Kim Ok-Hee,Cho Sun Wook,Lee Dae Ho,Kim Young-Bum.High-phytate/low-calcium diet is a risk factor for crystal nephropathies, renal phosphate wasting, and bone loss[EB/OL].(2025-03-28)[2025-04-28].https://www.biorxiv.org/content/10.1101/816512.点此复制
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