Overcoming non-small cell lung cancer radiation resistance by modulating the tumor-immune ecosystem
Overcoming non-small cell lung cancer radiation resistance by modulating the tumor-immune ecosystem
Abstract Non-small-cell lung cancer is the leading cause of cancer death worldwide. Although radiotherapy is an effective treatment choice for early-stage cases, the 5-year survival rate of patients diagnosed in late-stages remains poor. Increasing evidence suggests that the local and systemic effects of radiotherapy dependent on the induced anti-tumor immune responses. We believe that an educated adaptation of radiotherapy plans based not only on the induced immune responses, but also on the tumor-immune ecosystem composition at the beginning of treatment might increase local tumor control. We propose two different mathematical models to evaluate the potential of the tumor-immune context to inform adaptation of treatment plans with the aim of improving outcomes.
¨￠lvarez-Arenas A.、Mirzaev I.、Santiago D.N.、Karreth F.A.、Torres-Roca J.、Enderling H.、Lewin T.、Piretto E.、Nizzero S.、Joshi T.V.、Karolak A.、Walker R.、Zervantonakis I.K.、Rishi A.、Alfonso J.C.L.
Instituto de Matema?ˉtica Aplicada a la Ciencia y la Ingenier?ˉa, Universidad de Castilla-La ManchaDepartment of Applied Mathematics, University of ColoradoH. Lee Moffitt Cancer Center & Research InstituteH. Lee Moffitt Cancer Center & Research InstituteH. Lee Moffitt Cancer Center & Research InstituteH. Lee Moffitt Cancer Center & Research InstituteH. Lee Moffitt Cancer Center & Research InstituteUniversita degli Studi di TorinoHouston Methodist Research Institute, Rice UniversityStuttgart Research Center Systems Biology, University of StuttgartH. Lee Moffitt Cancer Center & Research InstituteH. Lee Moffitt Cancer Center & Research InstituteDepartment of Cell Biology, Harvard Medical SchoolH. Lee Moffitt Cancer Center & Research InstituteBraunschweig Integrated Centre of Systems Biology, Technische Universit?t
肿瘤学医学研究方法基础医学
¨￠lvarez-Arenas A.,Mirzaev I.,Santiago D.N.,Karreth F.A.,Torres-Roca J.,Enderling H.,Lewin T.,Piretto E.,Nizzero S.,Joshi T.V.,Karolak A.,Walker R.,Zervantonakis I.K.,Rishi A.,Alfonso J.C.L..Overcoming non-small cell lung cancer radiation resistance by modulating the tumor-immune ecosystem[EB/OL].(2025-03-28)[2025-05-05].https://www.biorxiv.org/content/10.1101/458372.点此复制
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