Mouse Auditory Cortex Undergoes Asynchronous Maturation in the Right and Left Hemispheres

Despite the significance of lateralized auditory processing in human cognition, there are limited studies in animal models exploring the developmental mechanisms of this cortical specialization. Here, we find that cellular and network signs of maturity in the Auditory Cortex (ACx) appear earlier in the right hemisphere in male mice. We further demonstrate that persistent, experience dependent map reorganization is confined to the hemisphere that is actively maturing and can be differentially engaged by temporally limited manipulations of the sensory environment. Our data suggests that differential timing in hemisphere development could lead to lateralized auditory functioning.