Divergent behavioral responses in protracted opioid withdrawal in male and female C57BL/6J mice
Divergent behavioral responses in protracted opioid withdrawal in male and female C57BL/6J mice
Abstract Persons suffering from opioid use disorder (OUD) experience long-lasting dysphoric symptoms well into extended periods of withdrawal. This protracted withdrawal syndrome is notably characterized by heightened anxiety. Here we investigate if an exacerbated withdrawal model of acute morphine dependence results in lasting behavioral adaptation 6 weeks into forced abstinence. We found that our exacerbated morphine withdrawal paradigm produced distinct impairments in elevated-plus maze, open field, and social interaction tests in male and female mice. These findings will be relevant for future investigation examining the neural mechanisms underlying these behaviors, and will aid in uncovering physiological sex differences in response to opioid withdrawal.
Schmidt Karl T.、Flanigan Meghan E.、Cogan Elizabeth S.、McElligott Zoe A.、Perez Patric J.、Bravo Isabel M.、Luster Brennon R.
Bowles Center for Alcohol Studies, University of North Carolina at Chapel HillBowles Center for Alcohol Studies, University of North Carolina at Chapel HillBowles Center for Alcohol Studies, University of North Carolina at Chapel HillBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill||Department of Psychiatry, University of North Carolina at Chapel Hill||Department of Pharmacology, University of North Carolina at Chapel HillBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill||Postbacculaureate Research Education Program, University of North Carolina at Chapel HillBowles Center for Alcohol Studies, University of North Carolina at Chapel HillBowles Center for Alcohol Studies, University of North Carolina at Chapel Hill
基础医学神经病学、精神病学生物科学研究方法、生物科学研究技术
Schmidt Karl T.,Flanigan Meghan E.,Cogan Elizabeth S.,McElligott Zoe A.,Perez Patric J.,Bravo Isabel M.,Luster Brennon R..Divergent behavioral responses in protracted opioid withdrawal in male and female C57BL/6J mice[EB/OL].(2025-03-28)[2025-04-24].https://www.biorxiv.org/content/10.1101/689521.点此复制
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