The mosquito vectors that sustained malaria transmission during the Magude project despite the combined deployment of indoor residual spraying, insecticide-treated nets and mass-drug administration
The mosquito vectors that sustained malaria transmission during the Magude project despite the combined deployment of indoor residual spraying, insecticide-treated nets and mass-drug administration
Abstract The “Magude project” aimed but failed to interrupt local malaria transmission in Magude district, southern Mozambique, by using a comprehensive package of interventions, including indoor residual spraying (IRS), pyrethroid-only long-lasting insecticide treated nets (LLINs) and mass-drug administration (MDA). Here we present detailed information on the vector species that sustained malaria transmission, their association with malaria incidence and behaviors, and their amenability to the implemented control interventions. Mosquitoes were collected monthly between May 2015 and October 2017 in six sentinel sites in Magude district, using CDC light traps both indoors and outdoors. Anopheles arabiensis was the main vector during the project, while An. funestus s.s., An. merus, An. parensis and An. squamosus likely played a secondary role. The latter two species have never previously been found positive for Plasmodium falciparum in southern Mozambique. The intervention package successfully reduced vector sporozoite rates in all species throughout the project. IRS was effective in controlling An. funestus s.s. and An. parensis, which virtually disappeared after its first implementation, but less effective at controlling An. arabiensis. Despite suboptimal use, LLINs likely provided significant protection against An. arabiensis and An. merus that sought their host largely indoors when people where in bed. Adding IRS on top of LLINs and MDA likely added value to the control of malaria vectors during the Magude project. Future malaria elimination attempts in the area could benefit from i) increasing the use of LLINs, ii) using longer-lasting IRS products to counteract the increase in vector densities observed towards the end of the high transmission season, and iii) a higher coverage with MDA to reduce the likelihood of human infection. However, additional interventions targeting vectors that survive IRS and LLINs b,y e.g. biting outdoors or indoors before people go to bed, will be likely needed to achieve local malaria elimination.
Galatas Beatriz、Alafo Celso、Comiche Kiba、Sherrard-Smith Ellie、Aide Pedro、Cuamba Nelson、Sa¨2te Francisco、Jotamo Dulcisaria、Koekemoer Lizette L.、M¨￠quina Mara、Montoya Lucia Fernandez、Cuamba Inocencia、Mart¨a-Soler Helena、Paaijmans Krijn P.、Bassat Quique
ISGlobal||Centro de Investiga??o em Sa¨2de de Manhi?a (CISM), Funda??o Manhi?aCentro de Investiga??o em Sa¨2de de Manhi?a (CISM), Funda??o Manhi?aCentro de Investiga??o em Sa¨2de de Manhi?a (CISM), Funda??o Manhi?aMRC Centre for Global Infectious Disease Analysis, Imperial College LondonCentro de Investiga??o em Sa¨2de de Manhi?a (CISM), Funda??o Manhi?a||Instituto Nacional da Sa¨2de, Minist¨|rio da Sa¨2dePrograma Nacional de Controlo da Mal¨￠ria, Minist¨|rio da Sa¨2de||PMI VectorLink Project, Abt Associates Inc.Centro de Investiga??o em Sa¨2de de Manhi?a (CISM), Funda??o Manhi?aPrograma Nacional de Controlo da Mal¨￠ria, Minist¨|rio da Sa¨2deWITS Research Institute for Malaria, Faculty of Health Sciences, University of the Witswatersrand and the Natitonal Institute for Communicable DiseasesCentro de Investiga??o em Sa¨2de de Manhi?a (CISM), Funda??o Manhi?aISGlobal||Centro de Investiga??o em Sa¨2de de Manhi?a (CISM), Funda??o Manhi?aCentro de Investiga??o em Sa¨2de de Manhi?a (CISM), Funda??o Manhi?aISGlobalISGlobal||Centro de Investiga??o em Sa¨2de de Manhi?a (CISM), Funda??o Manhi?a||Center for Evolution and Medicine, School of Life Sciences, Arizona State University||The Biodesign Center for Immunotherapy, Vaccines and Virotherapy, Arizona State University||Simon A. Levin Mathematical, Computational and Modeling Sciences Center, Arizona State UniversityISGlobal||Centro de Investiga??o em Sa¨2de de Manhi?a (CISM), Funda??o Manhi?a||ICREA||Pediatrics Department, Hospital Sant Joan de D¨|u, Universitat de Barcelona||Consorcio de Investigaci¨?n Biom¨|dica en Red de Epidemiolog¨aa y Salud P¨2blica (CIBERESP)
医学研究方法预防医学昆虫学
Galatas Beatriz,Alafo Celso,Comiche Kiba,Sherrard-Smith Ellie,Aide Pedro,Cuamba Nelson,Sa¨2te Francisco,Jotamo Dulcisaria,Koekemoer Lizette L.,M¨￠quina Mara,Montoya Lucia Fernandez,Cuamba Inocencia,Mart¨a-Soler Helena,Paaijmans Krijn P.,Bassat Quique.The mosquito vectors that sustained malaria transmission during the Magude project despite the combined deployment of indoor residual spraying, insecticide-treated nets and mass-drug administration[EB/OL].(2025-03-28)[2025-05-09].https://www.biorxiv.org/content/10.1101/2022.07.01.498466.点此复制
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