The effect of sample medication use on subsequent anti-VEGF agent selection for neovascular age-related macular degeneration
The effect of sample medication use on subsequent anti-VEGF agent selection for neovascular age-related macular degeneration
Abstract PurposeTo examine the effect of medication sample use (ranibizumab or aflibercept) on future anti-vascular endothelial growth factor (VEGF) agent selection in neovascular age-related macular degeneration (nvAMD). DesignRetrospective cohort study. MethodsnvAMD patients who underwent an initial anti-VEGF injection with a sample medication were compared to nvAMD control patients who never received a medication sample. Charts from 2017 through 2020 were reviewed for data regarding demographics, anti-VEGF agent selection, and visual acuity outcomes for both groups. Anti-VEGF agent selection for the first four injections and at one year were examined in both the sample and control groups. ResultsAdherence to the initial agent was high between first and subsequent injections (2nd, 3rd, 4th injection, and 1 year) in both sample (96.2%, 95.9%, 91.9%, 93.4%, respectively) and control groups (98.1%, 94.2%, 94.9%, 87.8%, respectively). Bevacizumab usage was significantly lower among eyes receiving samples relative to controls at the second (1.9% vs. 38.7%, p<0.001), third (3.1% vs. 41.3%, p<0.001), fourth injections (4.7% vs. 40.4%, p<0.001), and at 1 year (0% vs. 33.8%, p<0.001). Aflibercept usage was significantly higher in sample eyes relative to controls at the second (78.3% vs. 43.4%, p<0.001), third (76.3% vs. 41.5%, p<0.001), and fourth injections (76.7% vs. 43.4%, p<0.001), and at 1 year (77.0% vs. 52.7%, p<0.001). ConclusionsEyes receiving a sample anti-VEGF agent (ranibizumab or aflibercept) for their initial injection were less likely to receive bevacizumab at future visits relative to eyes that did not receive an anti-VEGF sample, even after one year of treatment.
Gragoudas Evangelos S.、Sobrin Lucia、Parikh Ravi、Wai Karen M.、Young Lucy H.、Vavvas Demetrios G.、Eliott Dean、Miller Joan W.、Wu David M.、Patel Nimesh A.、Begaj Tedi、Patil Sachi、Chen Evan、Kim Leo A.、Aronow Mary E.、Miller John B.、Huckfeldt Rachel、Husain Deeba、Mukai Shizuo、Kylstra Jan
Retina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical SchoolRetina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical SchoolDepartment of Ophthalmology and Visual Sciences, New York University School of Medicine||Manhattan Retina and Eye ConsultantsRetina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical SchoolRetina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical SchoolRetina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical SchoolRetina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical SchoolRetina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical SchoolRetina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical SchoolRetina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical SchoolRetina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical SchoolDepartment of Ophthalmology and Visual Sciences, New York University School of MedicineDepartment of Ophthalmology, University of CaliforniaRetina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical SchoolRetina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical SchoolRetina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical SchoolRetina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical SchoolRetina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical SchoolRetina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical SchoolRetina Service, Massachusetts Eye and Ear, Department of Ophthalmology, Harvard Medical School
眼科学医学研究方法
Gragoudas Evangelos S.,Sobrin Lucia,Parikh Ravi,Wai Karen M.,Young Lucy H.,Vavvas Demetrios G.,Eliott Dean,Miller Joan W.,Wu David M.,Patel Nimesh A.,Begaj Tedi,Patil Sachi,Chen Evan,Kim Leo A.,Aronow Mary E.,Miller John B.,Huckfeldt Rachel,Husain Deeba,Mukai Shizuo,Kylstra Jan.The effect of sample medication use on subsequent anti-VEGF agent selection for neovascular age-related macular degeneration[EB/OL].(2025-03-28)[2025-04-26].https://www.medrxiv.org/content/10.1101/2021.07.27.21261104.点此复制
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