AirLift: A Fast and Comprehensive Technique for Remapping Alignments between Reference Genomes
AirLift: A Fast and Comprehensive Technique for Remapping Alignments between Reference Genomes
AirLift is the first read remapping tool that enables users to quickly and comprehensively map a read set, that had been previously mapped to one reference genome, to another similar reference. Users can then quickly run downstream analysis of read sets for each latest reference release. Compared to the state-of-the-art method for remapping reads (i.e., full mapping), AirLift reduces the overall execution time to remap read sets between two reference genome versions by up to 27.4x. We validate our remapping results with GATK and find that AirLift provides high accuracy in identifying ground truth SNP/INDEL variants.
Mutlu Onur、Hajinazar Nastaran、Alser Mohammed、Kim Jeremie S、Cavlak Meryem Banu、Cali Damla Senol、Alkan Can、Firtina Can
生物科学研究方法、生物科学研究技术计算技术、计算机技术
Mutlu Onur,Hajinazar Nastaran,Alser Mohammed,Kim Jeremie S,Cavlak Meryem Banu,Cali Damla Senol,Alkan Can,Firtina Can.AirLift: A Fast and Comprehensive Technique for Remapping Alignments between Reference Genomes[EB/OL].(2025-03-28)[2025-05-15].https://www.biorxiv.org/content/10.1101/2021.02.16.431517.点此复制
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