Less is more - loss of EGFL7 improves memory by upregulation of VEGF-D
Less is more - loss of EGFL7 improves memory by upregulation of VEGF-D
Abstract Neural stem cells reside in a specialized neurogenic niche of the hippocampus termed the subgranular zone. Throughout life, they give rise to adult-born neurons in the dentate gyrus thereby contributing to learning and memory. Here, we report that neurons together with neural stem and precursor cells secrete the neurovascular protein epidermal growth factor-like protein 7 (EGFL7) to shape this niche. EGFL7 knock-out in vivo promoted adult neurogenesis generating neurons forming additional spines which permanently integrated into the neural circuit until old age. RNA-sequencing identified the cytokine VEGF-D as a major molecular driver of this process in vivo. In behavioral studies EGFL7 knock-out mice displayed stronger maintenance of memory suggesting longer-lasting spatial memory and improved memory consolidation in the hippocampus by modulation of pattern separation in young and aged mice. Taken together, EGFL7 is an upstream regulator of the VEGF-D in adult neurogenesis and a key regulator of learning and memory.
Mittmann Thomas、Zipp Frauke、Bicker Frank、Schumann Ulrike、Schumann Lana、Radyushkin Konstantin、Tegeder Irmgard、Meinhardt Matthias、Heinig Nora、Nimtschke Ute、R?hlecke Cora、Barth Kathrin、Tenzer Stefan、Schmidt Mirko HH、Maurer Christine、Baumgart Jan、Vasi? Verica
Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University Mainz||Institute of Physiology, University Medical Center of the Johannes Gutenberg University MainzFocus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University Mainz||Focus Program Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University Mainz||Department of Neurology, Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University MainzInstitute of Microscopic Anatomy and Neurobiology, University Medical Center of the Johannes Gutenberg University Mainz||Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University MainzInstitute of Anatomy, Medical Faculty Carl Gustav Carus, Technische Universit?t Dresden School of MedicineInstitute of Clinical Pharmacology, Goethe-University Hospital Frankfurt am MainFocus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University Mainz||Mouse Behavior Outcome Unit, Johannes Gutenberg University MainzInstitute of Clinical Pharmacology, Goethe-University Hospital Frankfurt am MainInstitute of Pathology, University Hospital Carl Gustav Carus, Technische Universit?t DresdenInstitute of Anatomy, Medical Faculty Carl Gustav Carus, Technische Universit?t Dresden School of MedicineInstitute of Anatomy, Medical Faculty Carl Gustav Carus, Technische Universit?t Dresden School of MedicineInstitute of Anatomy, Medical Faculty Carl Gustav Carus, Technische Universit?t Dresden School of MedicineInstitute of Anatomy, Medical Faculty Carl Gustav Carus, Technische Universit?t Dresden School of MedicineInstitute of Immunology, University Medical Center of the Johannes Gutenberg University Mainz||Focus Program Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg University MainzInstitute of Anatomy, Medical Faculty Carl Gustav Carus, Technische Universit?t Dresden School of MedicineInstitute of Microscopic Anatomy and Neurobiology, University Medical Center of the Johannes Gutenberg University Mainz||Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University Mainz||Institute of Clinical Pharmacology, Goethe-University Hospital Frankfurt am MainTranslational Animal Research Center (TARC), University Medical Center of the Johannes Gutenberg University MainzInstitute of Microscopic Anatomy and Neurobiology, University Medical Center of the Johannes Gutenberg University Mainz||Focus Program Translational Neuroscience (FTN), University Medical Center of the Johannes Gutenberg University Mainz
基础医学神经病学、精神病学分子生物学
Mittmann Thomas,Zipp Frauke,Bicker Frank,Schumann Ulrike,Schumann Lana,Radyushkin Konstantin,Tegeder Irmgard,Meinhardt Matthias,Heinig Nora,Nimtschke Ute,R?hlecke Cora,Barth Kathrin,Tenzer Stefan,Schmidt Mirko HH,Maurer Christine,Baumgart Jan,Vasi? Verica.Less is more - loss of EGFL7 improves memory by upregulation of VEGF-D[EB/OL].(2025-03-28)[2025-05-01].https://www.biorxiv.org/content/10.1101/2022.04.07.487327.点此复制
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