Enhanced selectivity of transcutaneous spinal cord stimulation by multielectrode configuration
Enhanced selectivity of transcutaneous spinal cord stimulation by multielectrode configuration
Abstract ObjectiveTranscutaneous spinal cord stimulation (tSCS) has been gaining momentum as a non-invasive rehabilitation approach to restore movement to paralyzed muscles after spinal cord injury (SCI). However, its low selectivity limits the types of movements that can be enabled and, thus, its potential applications in rehabilitation. ApproachIn this cross-over study design, we investigated whether muscle recruitment selectivity of individual muscles could be enhanced by multielectrode configurations of tSCS in 16 neurologically intact individuals. We hypothesized that due to the segmental innervation of lower limb muscles, we could identify muscle-specific optimal stimulation locations that would enable improved recruitment selectivity over conventional tSCS. We elicited leg muscle responses by delivering biphasic pulses of electrical stimulation to the lumbosacral enlargement using conventional and multielectrode tSCS. ResultsAnalysis of recruitment curve responses confirmed that multielectrode configurations could improve the rostrocaudal and lateral selectivity of tSCS. To investigate whether motor responses elicited by spatially selective tSCS were mediated by posterior root-muscle reflexes, each stimulation event was a paired pulse with a conditioning-test interval of 33.3 ms. Muscle responses to the second stimulation pulse were significantly suppressed, a characteristic of post-activation depression suggesting that spatially selective tSCS recruits proprioceptive fibers that reflexively activate muscle-specific motor neurons in the spinal cord. Moreover, the combination of leg muscle recruitment probability and segmental innervation maps revealed a stereotypical spinal activation map in congruence with each electrode’s position. SignificanceImprovements in muscle recruitment selectivity could be essential for the effective translation into stimulation protocols that selectively enhance single-joint movements in neurorehabilitation.
Peiffer J.D.、Fei Jie、Hawthorn Rachel、Keesey Rodolfo、Se¨￠?ez Ismael、Lombardi Lorenzo、Bryson Noah
Biomedical Engineering, Washington University in St. Louis||Division of Neurotechnology, Washington University School of Medicine in St. Louis||Biomedical Engineering, Northwestern UniversityBiomedical Engineering, Washington University in St. Louis||Division of Neurotechnology, Washington University School of Medicine in St. LouisBiomedical Engineering, Washington University in St. Louis||Division of Neurotechnology, Washington University School of Medicine in St. LouisBiomedical Engineering, Washington University in St. Louis||Division of Neurotechnology, Washington University School of Medicine in St. LouisBiomedical Engineering, Washington University in St. Louis||Division of Neurotechnology, Washington University School of Medicine in St. Louis||Neurosurgery, Washington University School of Medicine in St. LouisBiomedical Engineering, Washington University in St. Louis||Division of Neurotechnology, Washington University School of Medicine in St. LouisBiomedical Engineering, Washington University in St. Louis||Division of Neurotechnology, Washington University School of Medicine in St. Louis
神经病学、精神病学基础医学生物科学研究方法、生物科学研究技术
Peiffer J.D.,Fei Jie,Hawthorn Rachel,Keesey Rodolfo,Se¨￠?ez Ismael,Lombardi Lorenzo,Bryson Noah.Enhanced selectivity of transcutaneous spinal cord stimulation by multielectrode configuration[EB/OL].(2025-03-28)[2025-04-25].https://www.biorxiv.org/content/10.1101/2023.03.30.534835.点此复制
评论