Comparison of the pathogenicity and virus shedding of SARS CoV-2 VOC 202012/01 and D614G variant in hamster model
Comparison of the pathogenicity and virus shedding of SARS CoV-2 VOC 202012/01 and D614G variant in hamster model
Abstract The emergence of SARS-CoV-2 variants has posed a serious challenge to public health system and vaccination programs across the globe. We have studied the pathogenicity and virus shedding pattern of the SARS-CoV-2 VOC 202012/01 and compared with D614G variant in Syrian hamsters. VOC 202012/01 could produce disease in hamsters characterized by body weight loss and respiratory tract tropism but mild lung pathology. Further, we also documented that neutralizing antibodies developed against VOC 202012/01 could equally neutralize D614G variant. Higher load of VOC 202012/01 in the nasal wash specimens was observed during the first week of infection outcompeting the D614G variant. The findings suggest increased fitness of VOC 202012/01 to the upper respiratory tract which could lead to higher transmission. Further investigations are needed to understand the transmissibility of new variants. One-Sentence SummarySARS-CoV-2 VOC 202012/01 infected hamsters demonstrated high viral RNA shedding through the nasal secretions and significant body weight loss with mild lung pathology compared to the D614G variant.
Yadav Pragya D、Nyayanit Dimpal、Shete-Aich Anita、Sapkal Gajanan、Kumar Sanjay、Kumar Abhimanyu、Sarkale Prasad、Mohandas Sreelekshmy、Jain Rajlaxmi、Deshpande Gururaj、Kadam Manoj、Gawande Pranita、Patil Deepak Y、Abraham Priya
Indian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyDepartment of Neurosurgery, Command Hospital (Southern Command), Armed Forces Medical CollegeIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of VirologyIndian Council of Medical Research-National Institute of Virology
基础医学微生物学生物科学研究方法、生物科学研究技术
Yadav Pragya D,Nyayanit Dimpal,Shete-Aich Anita,Sapkal Gajanan,Kumar Sanjay,Kumar Abhimanyu,Sarkale Prasad,Mohandas Sreelekshmy,Jain Rajlaxmi,Deshpande Gururaj,Kadam Manoj,Gawande Pranita,Patil Deepak Y,Abraham Priya.Comparison of the pathogenicity and virus shedding of SARS CoV-2 VOC 202012/01 and D614G variant in hamster model[EB/OL].(2025-03-28)[2025-06-25].https://www.biorxiv.org/content/10.1101/2021.02.25.432136.点此复制
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