Immunogenicity of heterologous BNT162b2 booster in fully vaccinated individuals with CoronaVac against SARS-CoV-2 variants Delta and Omicron: the Dominican Republic Experience
Leon Patricia Jorge Aidelis Vogels Chantal B. F. Miric Marija Brache Vivian De la Cruz Elena Yildirim Inci Downing Randy Ko Albert Omer Saad B. Vermund Sten H. Iwasaki Akiko Billig Kendall Razeq Jafar Breban Mallery I. P¨|rez-Then Eddy Muyombwe Anthony De los Santos Margarita Monteiro Valter Silva Campbell Melissa Grubaugh Nathan D. Gagnon Emily Cochon Leila Pearson Claire Lucas Carolina
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Abstract
Abstract
The recent emergence of the SARS-CoV-2 Omicron variant is raising concerns because of its increased transmissibility and by its numerous spike mutations with potential to evade neutralizing antibodies elicited by COVID-19 vaccines. The Dominican Republic was among the first countries in recommending the administration of a third dose COVID-19 vaccine to address potential waning immunity and reduced effectiveness against variants. Here, we evaluated the effects of a heterologous BNT162b2 mRNA vaccine booster on the humoral immunity of participants that had received a two-dose regimen of CoronaVac, an inactivated vaccine used globally. We found that heterologous CoronaVac prime followed by BNT162b2 booster regimen induces elevated virus-specific antibody levels and potent neutralization activity against the ancestral virus and Delta variant, resembling the titers obtained after two doses of mRNA vaccines. While neutralization of Omicron was undetectable in participants that had received a two-dose regimen of CoronaVac vaccine, BNT162b2 booster resulted in a 1.4-fold increase in neutralization activity against Omicron, compared to two-dose mRNA vaccine. Despite this increase, neutralizing antibody titers were reduced by 6.3-fold and 2.7-fold for Omicron compared to ancestral and Delta variant, respectively. Surprisingly, previous SARS-CoV-2 infection did not affect the neutralizing titers for Omicron in participants that received the heterologous regimen. Our findings have immediate implications for multiples countries that previously used a two-dose regimen of CoronaVac and reinforce the notion that the Omicron variant is associated with immune escape from vaccines or infection-induced immunity, highlighting the global need for vaccine boosters to combat the impact of emerging variants.引用本文复制引用
Leon Patricia,Jorge Aidelis,Vogels Chantal B. F.,Miric Marija,Brache Vivian,De la Cruz Elena,Yildirim Inci,Downing Randy,Ko Albert,Omer Saad B.,Vermund Sten H.,Iwasaki Akiko,Billig Kendall,Razeq Jafar,Breban Mallery I.,P¨|rez-Then Eddy,Muyombwe Anthony,De los Santos Margarita,Monteiro Valter Silva,Campbell Melissa,Grubaugh Nathan D.,Gagnon Emily,Cochon Leila,Pearson Claire,Lucas Carolina.Immunogenicity of heterologous BNT162b2 booster in fully vaccinated individuals with CoronaVac against SARS-CoV-2 variants Delta and Omicron: the Dominican Republic Experience[EB/OL].(2025-03-28)[2026-02-01].https://www.medrxiv.org/content/10.1101/2021.12.27.21268459.学科分类
医药卫生理论/预防医学/基础医学
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