基于全球专利的Bt抗虫基因研发态势分析与展望

Purpose/Significance] The huge economic benefits of Bt insect resistant genes have attracted great attention of relevantresearch institutions and enterprises at home and abroad, and these genes and technologies are transformed into their own exclusiverights by using intellectual property rights. Through statistical analysis of Bt insect resistant gene patents collected in 126 countries andregions around the world, this paper provides a reference for China in the development and industrial application of Bt insect resistantgenes. [Method/Process] Based on the Global Patent Database of Smart Bud (PatSnap), the title, abstract and claim of the patent weretaken as the focus of the search, and the patent analysis method was used to statistically analyze the Bt insect-resistant transgenic patentscollected in the past 30 years since 1992. In the process of Bt anti-insect gene research, a large number of patent data were produced.After data cleaning, the "Bt strain", "detection method", "Bt insecticidal reagent" and other patents unrelated to the anti-insect gene wereeliminated, and 2,988 patents were obtained, all of which were invention patents. The research status, research hotspots and development trends of global Bt pest resistance genes were studied from the aspects of total patent applications and trend, gene family classification,national/regional distribution, key technology fields, technology flow, institutional competitiveness, patent legalization status, andcompound trait patents. [Results/Conclusions] Results show that the global Bt insect-resistant gene technology patent research anddevelopment trends, research hotspots and distribution technology gradually remain stable, the trend of patent application and disclosurein China is growing at the same time as that in the world. China's patent applications account for an increasing proportion of the globalpatent applications. But compared with international patent quality, there is still a gap between China and other countries. Multinationalcompanies are the main body of Bt pest resistance gene market competition, and Chinese applicants are mainly scientific researchinstitutions and universities. The cry1 family is the main target of Bt pest resistance gene patent application. The crystallized protein ofBacillus is a hot topic at present. The United States is the exporting country of Bt insect-resistant gene technology, while China is still inthe stage of technology input. The patent failure rate of Bt insect resistance gene is much lower than the average level in this field. Thereis great potential in the study of fusion genes and gene superposition composite traits. Finally, the development prospects of Bt insectresistance gene technology in China were discussed.