Closed-loop stimulation of the medial septum terminates epileptic seizures
Closed-loop stimulation of the medial septum terminates epileptic seizures
ABSTRACT Temporal lobe epilepsy with distributed hippocampal seizure foci is often intractable and its secondary generalization might lead to sudden death. Early termination through spatially extensive hippocampal intervention is not feasible directly, due to its large size and irregular shape. In contrast, the medial septum (MS) is a promising target to govern hippocampal oscillations through its divergent connections to both hippocampi. Combining this ‘proxy intervention’ concept and precisely timed stimulation, we report here that closed-loop MS electrical stimulation can quickly terminate intrahippocampal seizures and suppress secondary generalization in a rat kindling model. Precise stimulus timing governed by internal seizure rhythms was essential. Cell-type-specific stimulation revealed that precisely timed activation of MS GABAergic neurons underlay the effects. Our concept of phase-targeted proxy stimulation for intervening pathological oscillations can be extrapolated to other neurological and psychiatric disorders, and its current embodiment can be directly translated into clinical application.
Harangoz¨? M¨￠rk、Pedraza Lizeth、F?ldi Tam¨￠s、Ber¨|nyi Antal、Takeuchi Yuichi、Koz¨￠k G¨￠bor
MTA-SZTE ??Momentum?ˉ Oscillatory Neuronal Networks Research Group, Department of Physiology, University of SzegedMTA-SZTE ??Momentum?ˉ Oscillatory Neuronal Networks Research Group, Department of Physiology, University of SzegedMTA-SZTE ??Momentum?ˉ Oscillatory Neuronal Networks Research Group, Department of Physiology, University of SzegedMTA-SZTE ??Momentum?ˉ Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged||HCEMM-SZTE Magnetotherapeutics Research Group, University of Szeged||Neuroscience Institute, New York UniversityMTA-SZTE ??Momentum?ˉ Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged||Department of Neuropharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City UniversityMTA-SZTE ??Momentum?ˉ Oscillatory Neuronal Networks Research Group, Department of Physiology, University of Szeged
神经病学、精神病学基础医学医学研究方法
Harangoz¨? M¨￠rk,Pedraza Lizeth,F?ldi Tam¨￠s,Ber¨|nyi Antal,Takeuchi Yuichi,Koz¨￠k G¨￠bor.Closed-loop stimulation of the medial septum terminates epileptic seizures[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/2020.03.09.982827.点此复制
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