Intracranial electroencephalography reveals effector-independent evidence accumulation dynamics in multiple human brain regions
Intracranial electroencephalography reveals effector-independent evidence accumulation dynamics in multiple human brain regions
Abstract Neural representations of perceptual decision formation that are abstracted from specific motor requirements have previously been identified in humans using non-invasive electrophysiology, however, it is currently unclear where these originate in the brain. Here, we capitalized on the high spatiotemporal precision of intracranial EEG to localize such abstract decision signals. Presurgical epilepsy patients judged the direction of random-dot stimuli and responded either with a speeded button press (N=23), or vocally, after a randomized delay (N=11). We found a widely distributed motor-independent network of regions where high-frequency activity exhibited key characteristics consistent with evidence accumulation, including a gradual build-up that was modulated by the strength of the sensory evidence, and an amplitude that predicted subjects’ choice accuracy and response time. Our findings offer a new view on the brain networks governing human decision making.
Espinal Elizabeth、O?ˉConnell Redmond G.、Bickel Stephan、Kelly Simon P.、Mehta Ashesh D.、Gherman Sabina、Markowitz Noah、Tostaeva Gelana
The Feinstein Institutes for Medical Research, Northwell Health||Department of Psychological and Brain Sciences, Drexel UniversityTrinity College Institute of Neuroscience, Trinity College Dublin||School of Psychology, Trinity College DublinThe Feinstein Institutes for Medical Research, Northwell Health||Departments of Neurology and Neurosurgery, Zucker School of Medicine at Hofstra/Northwell||Center for Biomedical Imaging and Neuromodulation, Nathan Kline InstituteSchool of Electrical and Electronic Engineering and UCD Centre for Biomedical Engineering, University College DublinThe Feinstein Institutes for Medical Research, Northwell Health||Departments of Neurology and Neurosurgery, Zucker School of Medicine at Hofstra/NorthwellThe Feinstein Institutes for Medical Research, Northwell HealthThe Feinstein Institutes for Medical Research, Northwell HealthThe Feinstein Institutes for Medical Research, Northwell Health
神经病学、精神病学基础医学生物科学研究方法、生物科学研究技术
Espinal Elizabeth,O?ˉConnell Redmond G.,Bickel Stephan,Kelly Simon P.,Mehta Ashesh D.,Gherman Sabina,Markowitz Noah,Tostaeva Gelana.Intracranial electroencephalography reveals effector-independent evidence accumulation dynamics in multiple human brain regions[EB/OL].(2025-03-28)[2025-08-22].https://www.biorxiv.org/content/10.1101/2023.04.10.536314.点此复制
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