Fascicles Split or Merge Every ~560 Microns Within the Human Cervical Vagus Nerve
Fascicles Split or Merge Every ~560 Microns Within the Human Cervical Vagus Nerve
1 Abstract Vagus nerve stimulation (VNS) is FDA approved for stroke rehabilitation, epilepsy and depression; however, the underlying vagus functional anatomy underlying the implant is poorly understood. We used microCT to quantify fascicular structure and neuroanatomy within human cervical vagus nerves. Fascicles split or merged every ~560 μm (17.8 ± 6.1 events/cm). The high degree of splitting and merging of fascicles in humans may explain the clinical heterogeneity in patient responses.
Zhang Jing、Grill Warren M.、Upadhye Aniruddha R.、Al Lababidi Luna、Menendez Dhariyat M.、Settell Megan L.、Pelot Nicole A.、Gustafson Kenneth J.、Shoffstall Andrew J.、Jenkins Michael W.、Wilson David L.、Buyukcelik Ozge N.、Kolluru Chaitanya、Ahmad Sami S.、Tatsuoka Curtis、Druschel Lindsey、Ludwig Kip A.
Department of Population and Quantitative Health Sciences, Case Western Reserve UniversityDepartment of Biomedical Engineering, Duke University||Department of Electrical and Computer Engineering, Duke University||Department of Neurobiology, Duke University||Department of Neurosurgery, Duke UniversityDepartment of Biomedical Engineering, Case Western Reserve University||APT Center, Louis Stokes Cleveland VA Medical CenterDepartment of Biomedical Engineering, Case Western Reserve UniversityDepartment of Biomedical Engineering, Case Western Reserve University||APT Center, Louis Stokes Cleveland VA Medical CenterDepartment of Biomedical Engineering, University of Wisconsin-MadisonDepartment of Biomedical Engineering, Duke UniversityDepartment of Biomedical Engineering, Case Western Reserve University||FES Center, Louis Stokes Cleveland VA Medical CenterDepartment of Biomedical Engineering, Case Western Reserve University||APT Center, Louis Stokes Cleveland VA Medical CenterDepartment of Biomedical Engineering, Case Western Reserve UniversityDepartment of Biomedical Engineering, Case Western Reserve UniversityDepartment of Biomedical Engineering, Case Western Reserve UniversityDepartment of Biomedical Engineering, Case Western Reserve UniversityDepartment of Biomedical Engineering, Case Western Reserve UniversityDepartment of Population and Quantitative Health Sciences, Case Western Reserve University||FES Center, Louis Stokes Cleveland VA Medical CenterDepartment of Biomedical Engineering, Case Western Reserve University||APT Center, Louis Stokes Cleveland VA Medical CenterDepartment of Biomedical Engineering, University of Wisconsin-Madison||Department of Neurosurgery, University of Wisconsin-Madison
神经病学、精神病学基础医学医学研究方法
Zhang Jing,Grill Warren M.,Upadhye Aniruddha R.,Al Lababidi Luna,Menendez Dhariyat M.,Settell Megan L.,Pelot Nicole A.,Gustafson Kenneth J.,Shoffstall Andrew J.,Jenkins Michael W.,Wilson David L.,Buyukcelik Ozge N.,Kolluru Chaitanya,Ahmad Sami S.,Tatsuoka Curtis,Druschel Lindsey,Ludwig Kip A..Fascicles Split or Merge Every ~560 Microns Within the Human Cervical Vagus Nerve[EB/OL].(2025-03-28)[2025-08-04].https://www.biorxiv.org/content/10.1101/2021.11.09.467343.点此复制
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