Saliva metabolome alterations after acute stress
Saliva metabolome alterations after acute stress
Abstract Major stress has systemic effects on the body that can have adverse consequences for physical and mental health. However, the molecular basis of these damaging effects remains incompletely understood. Here we use a longitudinal approach to characterise the acute systemic impact of major psychological stress in a pig model. We perform untargeted metabolomics on non-invasively-obtained saliva samples from pigs before and 24-hours after transfer to the novel physical and social environment of a slaughterhouse. The main molecular changes occurring include decreases in amino acids, B-vitamins, and amino acid-derived metabolites synthesized in B-vitamin-dependent reactions, as well as yet-unidentified metabolite features. Decreased levels of several of the identified metabolites are implicated in the pathology of human psychological disorders and neurodegenerative disease, suggesting a possible neuroprotective function. Our results provide a fingerprint of the acute effect of psychological stress on the metabolome and suggest candidate biomarkers with potential roles in stress-related disorders. One Sentence SummaryIdentification of metabolites decreased under acute psychological stress may lead to future discoveries for the prevention and treatment of stress-related disorders.
Bateson Melissa、Dupont Birkler Rune Isak、Wachsman Tal、Dong Yonghui、Adler-Abramovich Lihi、Cohen Hagit、Zohar Joseph、Shaham-Niv Shira、Morgan Liat、Yakobson Boris、Gazit Ehud、Carmi Lior
Biosciences Institute, Newcastle UniversityMetabolite Medicine Division, BLAVATNIK CENTER for Drug Discovery, Tel Aviv UniversityMetabolite Medicine Division, BLAVATNIK CENTER for Drug Discovery, Tel Aviv UniversityMetabolite Medicine Division, BLAVATNIK CENTER for Drug Discovery, Tel Aviv UniversityMetabolite Medicine Division, BLAVATNIK CENTER for Drug Discovery, Tel Aviv University||Department of Oral Biology, The Goldschleger School of Dental Medicine, Sackler Faculty of Medicine, Tel Aviv UniversityAnxiety and Stress Research Unit, Beer-Sheva Mental Health Center, Faculty of Health Sciences, Division of Psychiatry, Ben-Gurion University of the NegevThe Post-Trauma Center, Chaim Sheba Medical CenterMetabolite Medicine Division, BLAVATNIK CENTER for Drug Discovery, Tel Aviv UniversityShmunis School of Biomedicine and Cancer Research, Tel Aviv University||Biosciences Institute, Newcastle UniversityKimron Veterinary Institute, Ministry of Agriculture and Rural DevelopmentShmunis School of Biomedicine and Cancer Research, Tel Aviv University||Metabolite Medicine Division, BLAVATNIK CENTER for Drug Discovery, Tel Aviv UniversityThe Post-Trauma Center, Chaim Sheba Medical Center
基础医学生物化学生理学
Bateson Melissa,Dupont Birkler Rune Isak,Wachsman Tal,Dong Yonghui,Adler-Abramovich Lihi,Cohen Hagit,Zohar Joseph,Shaham-Niv Shira,Morgan Liat,Yakobson Boris,Gazit Ehud,Carmi Lior.Saliva metabolome alterations after acute stress[EB/OL].(2025-03-28)[2025-05-02].https://www.biorxiv.org/content/10.1101/2022.02.24.480641.点此复制
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