Coral: Clear and customizable visualization of human kinome data
Coral: Clear and customizable visualization of human kinome data
Protein kinases represent one ofthe largest gene families in eukaryotes and play roles in a wide range of cell signaling processes and human diseases, making them attractive targets for drug development. The human kinome is extensively featured inhigh-throughput studiesgenerating genomic, proteomic, and kinase profiling data. Current tools for visualizing kinase data in the context of the human kinome superfamily are limited to encoding data through the addition of nodes to a low-resolution image of the kinome tree. We present Coral, a user-friendly interactive webapplication for visualizing both quantitative and qualitative data. Unlike previous tools, Coral can encode data in three features (node color, node size, and branchcolor), allowsthreemodesofkinomevisualization (the traditional kinome tree as well as radial and dynamic-force networks) and generates high-resolution scalable vector graphic files suitable for publication without the need for refinement in graphic editing software. Due to its user-friendly, interactive, and highly customizable design, Coral is broadly applicable to high-throughput studies of the human kinome. The source code and web application are available at github.com/dphansti/Coral. html and phanstiel-lab.med.unc.edu/Coral respectively.
Metz Kathleen S.、Deoudes Erika M.、Jimenez-Ruiz Ivan、Aksoy Bulent Arman、Hammerbacher Jeff、Phanstiel Douglas H.、Gomez Shawn M.、Berginski Matthew E.
Curriculum in Genetics & Molecular Biology, University of North CarolinaThurston Arthritis Research Center, University of North CarolinaCurriculum in Bioinformatics & Computational Biology, University of North CarolinaDepartment of Microbiology and Immunology, Medical University of South CarolinaDepartment of Microbiology and Immunology, Medical University of South CarolinaThurston Arthritis Research Center, University of North Carolina||Department of Cell Biology & Physiology, University of North CarolinaJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University||Department of Pharmacology, University of North CarolinaJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University||Department of Pharmacology, University of North Carolina
生物科学研究方法、生物科学研究技术基础医学生物化学
Metz Kathleen S.,Deoudes Erika M.,Jimenez-Ruiz Ivan,Aksoy Bulent Arman,Hammerbacher Jeff,Phanstiel Douglas H.,Gomez Shawn M.,Berginski Matthew E..Coral: Clear and customizable visualization of human kinome data[EB/OL].(2025-03-28)[2025-05-17].https://www.biorxiv.org/content/10.1101/330274.点此复制
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