A causal role of the human left temporoparietal junction in computing social influence during goal-directed learning
A causal role of the human left temporoparietal junction in computing social influence during goal-directed learning
Abstract The human temporoparietal junction (TPJ) is a brain area crucial for processing social information. Although brain stimulation studies have started to explore the causal function of TPJ under social contexts, few have explicitly considered bilateral TPJ as target regions. Here, leveraging non-invasive continuous theta-burst stimulation (cTBS) and hierarchical Bayesian computational modeling, we tested whether left or right TPJ (with vertex as control) is causally involved in how dissenting choices by others influence individuals’ choice adjustments in goal-directed learning. In our social learning paradigm, participants (N = 31) first made their private decision, and then were allowed to re-adjust their choices after observing choices of four other players. Behaviorally, we show that disruption of the left, but not the right TPJ, weakened participants’ choice adjustment and delayed their response speed when confronted with dissenting information from the other players. Computationally, disrupting activity in the left TPJ attenuated the degree of computing social influence during choice adjustment, whereas the extent to which how observational learning from others’ choices was integrated into direct learning remained intact. Together, our results provide evidence for the causal role of left TPJ in social influence during goal-directed learning and shed light on the relational function (with respect to oneself) of the TPJ in social cognition.
Zhang Lei、Zhao Ke、Fu Xiaolan、Lamm Claus、Kandil Farid I.、Hilgetag Claus C.、Gl?scher Jan
Institute of Systems Neuroscience, University Medical Center Hamburg-Eppendorf||Social, Cognitive and Affective Neuroscience Unit, Department of Cognition, Emotion, and Methods in Psychology, Faculty of Psychology, University of ViennaState Key Laboratory of Brain and Cognitive Science, Institute of Psychology, Chinese Academy of Sciences||Department of Psychology, University of Chinese Academy of SciencesState Key Laboratory of Brain and Cognitive Science, Institute of Psychology, Chinese Academy of Sciences||Department of Psychology, University of Chinese Academy of SciencesSocial, Cognitive and Affective Neuroscience Unit, Department of Cognition, Emotion, and Methods in Psychology, Faculty of Psychology, University of Vienna||Vienna Cognitive Science Hub, University of ViennaInstitute of Computational Neuroscience, University Medical Center Hamburg-Eppendorf||Department of Neurology, Charit¨| ¨C Universit?tsmedizin BerlinInstitute of Computational Neuroscience, University Medical Center Hamburg-Eppendorf||Department of Health Sciences, Boston UniversityInstitute of Systems Neuroscience, University Medical Center Hamburg-Eppendorf
生物科学现状、生物科学发展生物科学研究方法、生物科学研究技术人类学
Zhang Lei,Zhao Ke,Fu Xiaolan,Lamm Claus,Kandil Farid I.,Hilgetag Claus C.,Gl?scher Jan.A causal role of the human left temporoparietal junction in computing social influence during goal-directed learning[EB/OL].(2025-03-28)[2025-05-05].https://www.biorxiv.org/content/10.1101/2022.06.13.495824.点此复制
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