Exome sequencing of 457 autism families recruited online provides evidence for novel ASD genes
Exome sequencing of 457 autism families recruited online provides evidence for novel ASD genes
Autism spectrum disorder (ASD) is a genetically heterogeneous condition, caused by a combination of rare de novo and inherited variants as well as common variants in at least several hundred genes. However, significantly larger sample sizes are needed to identify the complete set of genetic risk factors. We conducted a pilot study for SPARK (SPARKForAutism.org) of 457 families with ASD, all consented online. Whole exome sequencing (WES) and genotyping data were generated for each family using DNA from saliva. We identified variants in genes and loci that are clinically recognized causes or significant contributors to ASD in 10.4% of families without previous genetic findings. Additionally, we identified variants that are possibly associated with autism in an additional 3.4% of families. A meta-analysis using the TADA framework at a false discovery rate (FDR) of 0.2 provides statistical support for 34 ASD risk genes with at least one damaging variant identified in SPARK. Nine of these genes (BRSK2, DPP6, EGR3, FEZF2, ITSN1, KDM1B, NR4A2, PAX5 and RALGAPB) are newly emerging genes in autism, of which BRSK2 has the strongest statistical support as a risk gene for autism (TADA q-value = 0.0015). Future studies leveraging the thousands of individuals with ASD that have enrolled in SPARK are likely to further clarify the genetic risk factors associated with ASD as well as allow accelerate autism research that incorporates genetic etiology.
Albright Charles、O?ˉBrien Kaela、Daniels Amy M.、Clark Renee D.、Rosenberg Cordelia R.、Sahin Mustafa、Salomatov Andrei、Thomas Carrie、Schultz Robert T.、Schweers Kathryn A.、Shah Swapnil、Shen Yufeng、Shocklee Amanda D.、Takahashi Nicole、Simon Laura、Stephens Alexandra N.、Smith Kaitlin、Vernoia Brianna M.、Volfovsky Natalia、Wallace Jermel、Walston Corrie H.、Wang Tianyun、White Loran Casey、Wodka Ericka L.、Xu Simon、Yang Wha S.、Yinger Meredith、Zaydens Hana、Zhou Xueya、Astrovskaya Irina、Bardett Nicole、Berry-Kravis Elizabeth、Brueggeman Leo、Butter Eric M.、Callahan Kristen、Cartner Lindsey A.、Chatha Ahmad S.、Chung Wendy K.、Marini Richard、Mason Andrew、Tjernagel Jennifer、Huang-Storms Lark Y.、Hutter Hanna、Jensen William、Jordy Michelle、Juarez A. Pablo、Kaplan Hannah E.、Kent Matt、Korchina Viktoriya、Krentz Anthony D.、Schneider Hoa Lam、Lawson Noah、Layman Kevin、Lee Sandra、Martin Christa Lese、Li Hai、Lord Catherine、Zhou Xueya、Turner Tychele N.、Wang Tianyun、Snyder LeeAnne Green、Muzny Donna M.、The SPARK Consortium、Volfovsky Natalia、Shen Yufeng、Chung Wendy K.、Abbeduto Leonard、Ace Andrea J.、Amaral David G.、Amatya Alpha、Annett Robert D.、Grosvenor Luke P.、Gulsrud Amanda C.、Hall Jacob B.、Han Bing、Hauf Brenda、Hayes Caitlin、Herbert Lynette M.、Horner Susannah、Cohen Cheryl、Courchesne Eric、Currin Mary Hannah、DeMarco Lindsey、Dennis Megan Y.、Ding Yan、Dinh Huyen、Doan Ryan、Doddapaneni HarshaVardhan、Eichler Evan E.、Eng Christine、Feliciano Pamela、Francis Sunday、Ganesan Swami、Gerdts Jennifer A.、Goin-Kochel Robin P.、J.Griswold Anthony、Feliciano Pamela、Nicholson Amy、Ochoa-Lubinoff Cesar、Orobio Jessica、Ousley Opal Y.、Pandey Juhi、Piven Joseph、Pramparo Tiziano、Prock Lisa M.、Rachubinski Angela L.、McKenzie Alexander P.、Morrier Michael J.、Murali Shwetha、Neely Jason、Nessner Caitlin、Ruzzo Elizabeth、Lechniak Holly、Soucy Aubrie、Sutcliffe James S.、Marzano Gabriela、Koomar Tanner、Hilscher Brittani A.、Thomas Taylor、Bashar Asif、Gibbs Richard A.、Hamer Kira E.、Coury Daniel Lee、Pacheco Lillian D.、Garrett Michael、Carriero Nicholas、Smith Christopher J.、Eldred Sara、Russo-Ponsaran Nicole、Jones Mark、Acampado John、Sandhu Sophia、O?ˉConnor Eirene、Rajbhandari Kshitij、Gunderson Jaclyn、Swanson Amy、Robertson Beverly E.、Lillie Natasha、White Sabrina、Mallardi Malcolm D.、Camba Alexies、Singh Vini、Liu Xiuping、Snyder LeeAnne G.、Qi Hongjian、Law J. Kiely、Sarver Dustin E.、Warren Zachary、Barnard Rebecca、Fatemi Ali、Chin Wubin、Zhang Haicang、Stock Colleen M.、Zang Lan、Veenstra-Vanderweele Jeremy、Remington Rick、Esler Amy、Istephanous Dalia、Hanna Nathan、Brooks Elizabeth、Barnard Rebecca A.、Manning Patricia、Gibbs Richard A.、Momin Zeineen、Santangelo Susan、Hepburn Susan L.、Tafolla Maira、Lash Alex E.、Hu Jianhong、Hsieh Alexander、O?ˉRoak Brian J.、Popp Marc、Fox Emily A.、Jacob Suma、Gutierrez Anibal、Geschwind Daniel H.、McCracken James T.、Sabo Aniko、Harris Nina、Alessandri Michael、Brueggeman Leo、Kitaygorodsky Alex、Turner Tychele N.、Michaelson Jacob J.、Muzny Donna、Li Deana、Eichler Evan E.、Beaudet Arthur、Harkins Christina、Qiu Shanping、Thompson Samantha、Fischer Gregory、Michaelson Jacob J.、Haley Monica、Paolicelli Anna Marie、Sabo Aniko、Booker Stephanie、Sutcliffe James S.、Fisk Ian、Hsieh Alexander、Rice Catherine E.、Wang Jiayao、Zhao Haoquan、Bernier Raphael A.、Matthews Emily T.、Heyman Michelle、Wasserburg Lucy、Cubells Joseph F.、Rana Rishiraj、Dichter Gabriel S.、Hale Melissa N.、Kanne Stephen、Pierce Karen L.、Manoharan Julie、Gruber Angela J.、O?ˉRoak Brian J.、Erickson Craig A.、Metre Bonnie Van、Yu Timothy、Scherr Jessica、Astrovskaya Irina、Lamarche Elena、Geisheker Madeleine R.、Simon Andrea R.、Beeson Landon、Fombonne Eric J.、Gazestani Vahid、Butler Martin E.、Bahl Ethan、Brewster Stephanie J.、Lee Soo J.、Plate Samantha、Landa Rebecca J.、Myers Vincent J.、Balasubramanian Adithya、Pawlowski Katherine G.、Skinner Steve、Friedman Sandra L.、Rigby Chris、Roeder Katherine、Shaikh Tamim、Soorya Latha V.、Arriaga Ivette、Carpenter Sarah
Division of Pediatric Psychology and Neuropsychology, Nationwide Children?ˉs HospitalDepartment of Psychiatry and Behavioral Neuroscience, Cincinnati Children?ˉs Hospital Medical Center - Research FoundationSimons FoundationDepartment of Psychiatry, University of North Carolina at Chapel HillDepartment of Pediatrics, University of Colorado School of MedicineDepartment of Neurology, Boston Children?ˉs HospitalSimons FoundationDepartment of Psychiatry and Behavioral Neuroscience, Cincinnati Children?ˉs Hospital Medical Center - Research FoundationCenter for Autism Research, Children?ˉs Hospital of PhiladelphiaDepartment of Psychiatry, Rush University Medical CenterSimons FoundationDepartment of Systems Biology, Columbia UniversityThompson Center for Autism and Neurodevelopmental Disorders, University of MissouriThompson Center for Autism and Neurodevelopmental Disorders, University of MissouriDepartment of Psychiatry, University of MinnesotaSimons FoundationMIND Institute and Department of Psychiatry and Behavioral Sciences, University of CaliforniaSimons FoundationSimons FoundationDepartment of Psychiatry and Behavioral Sciences, Emory Autism Center, Emory UniversityDepartment of Psychiatry, University of North Carolina at Chapel HillDepartment of Genome Sciences, University of Washington School of MedicineSimons FoundationCenter for Autism and Related Disorders, Kennedy Krieger InstituteSimons FoundationDepartment of Psychiatry and Biobehavioral Sciences, University of CaliforniaDepartment of Psychiatry and Behavioral Sciences, Emory Autism Center, Emory UniversitySimons FoundationDepartment of Systems Biology, Columbia UniversitySimons FoundationVanderbilt Kennedy Center, Vanderbilt University Medical CenterDepartment of Neurological Sciences, Rush University Medical Center||Department of Pediatrics, Rush University Medical Center||Department of Biochemistry, Rush University Medical CenterDepartment of Psychiatry, University of Iowa Carver College of MedicineDivision of Pediatric Psychology and Neuropsychology, Nationwide Children?ˉs HospitalDepartment of Pediatrics, University of Mississippi Medical CenterSimons FoundationSimons FoundationSimons Foundation||Department of Pediatrics, Columbia University Medical CenterSimons FoundationResearch, Southwest Autism Research and Resource CenterSimons FoundationDepartment of Psychiatry, Oregon Health & Science UniversityCenter for Autism and Related Disorders, Kennedy Krieger InstituteSimons FoundationDepartment of Psychiatry, University of North Carolina at Chapel HillDepartment of Pediatrics, Vanderbilt University Medical CenterDepartment of Neurosciences, University of California, San Diego, School of MedicineSimons FoundationHuman Genome Sequencing Center, Baylor College of MedicinePreventionGeneticsDepartment of Psychology, University of MiamiSimons FoundationSimons FoundationHuman Genome Sequencing Center, Baylor College of MedicineAutism & Developmental Medicine Institute, Geisinger Autism & Developmental Medicine InstituteDepartment of Pediatrics, Rush University Medical CenterDepartment of Psychiatry, Weill Cornell MedicineDepartment of Systems Biology, Columbia UniversityDepartment of Genome Sciences, University of Washington School of MedicineDepartment of Genome Sciences, University of Washington School of MedicineSimons FoundationDepartment of Molecular and Human Genetics, Baylor College of MedicineSimons FoundationDepartment of Systems Biology, Columbia UniversitySimons Foundation||Department of Pediatrics, Columbia University Medical CenterMIND Institute and Department of Psychiatry and Behavioral Sciences, University of CaliforniaSimons FoundationMIND Institute and Department of Psychiatry and Behavioral Sciences, University of CaliforniaSimons FoundationDepartment of Pediatrics, University of Mississippi Medical CenterSimons FoundationDepartment of Psychiatry and Biobehavioral Sciences, University of CaliforniaSimons FoundationSimons FoundationDepartment of Psychiatry, University of North Carolina at Chapel HillDivision of Pediatric Psychology and Neuropsychology, Nationwide Children?ˉs HospitalDepartment of Psychology, University of MiamiCenter for Autism Research, Children?ˉs Hospital of PhiladelphiaHugo W. Moser Research Institute at Kennedy KriegerDepartment of Neurosciences, University of California, San Diego, School of MedicineDepartment of Psychiatry, University of North Carolina at Chapel HillCenter for Autism Research, Children?ˉs Hospital of PhiladelphiaGenome Center, MIND Institute, Department of Biochemistry and Molecular Medicine, University of CaliforniaHuman Genome Sequencing Center, Baylor College of MedicineHuman Genome Sequencing Center, Baylor College of MedicineDepartment of Medicine, Boston Childrens HospitalHuman Genome Sequencing Center, Baylor College of MedicineDepartment of Genome Sciences, University of Washington School of Medicine||University of Washington, Howard Hughes Medical InstituteDepartment of Molecular and Human Genetics, Baylor College of MedicineSimons FoundationDepartment of Psychiatry, University of MinnesotaSimons FoundationDepartment of Psychiatry and Behavioral Sciences, University of WashingtonDepartment of Pediatrics, Baylor College of MedicineJohn P. Hussman Institute for Human Genomics, University of Miami Miller School of MedicineSimons FoundationDepartment of Pediatrics, Vanderbilt University Medical CenterDepartment of Pediatrics, Rush University Medical CenterDepartment of Pediatrics, Baylor College of MedicineDepartment of Psychiatry and Behavioral Sciences, Emory Autism Center, Emory UniversityCenter for Autism Research, Children?ˉs Hospital of PhiladelphiaDepartment of Psychiatry, University of North Carolina at Chapel HillDepartment of Neurosciences, University of California, San Diego, School of MedicineDepartment of Pediatrics, Boston Children?ˉs HospitalDepartment of Pediatrics, University of Colorado School of MedicineCenter for Autism and Related Disorders, Kennedy Krieger InstituteDepartment of Psychiatry and Behavioral Sciences, Emory Autism Center, Emory UniversityDepartment of Genome Sciences, University of Washington School of MedicineCenter for Autism and Related Disorders, Kennedy Krieger InstituteHuman Genome Sequencing Center, Baylor College of MedicineDepartment of Neurology, University of CaliforniaDepartment of Psychiatry, Rush University Medical CenterDepartment of Medicine, Boston Childrens HospitalDepartment of Molecular Physiology & Biophysics, Vanderbilt UniversityDepartment of Pediatrics, Baylor College of MedicineDepartment of Psychiatry, University of Iowa Carver College of MedicineMIND Institute and Department of Psychiatry and Behavioral Sciences, University of CaliforniaDepartment of Psychiatry, University of Iowa Carver College of MedicineSimons FoundationDepartment of Molecular and Human Genetics, Baylor College of MedicineDepartment of Psychiatry and Behavioral Sciences, University of WashingtonDivision of Pediatric Psychology and Neuropsychology, Nationwide Children?ˉs HospitalDepartment of Psychiatry, Oregon Health & Science UniversityDepartment of Pharmacology and Toxicology, University of Mississippi Medical CenterSimons FoundationResearch, Southwest Autism Research and Resource CenterDivision of Pediatric Psychology and Neuropsychology, Nationwide Children?ˉs HospitalDepartment of Behavioral Sciences, Rush University Medical CenterDivision of Pediatric Psychology and Neuropsychology, Nationwide Children?ˉs HospitalSimons FoundationDepartment of Psychiatry and Biobehavioral Sciences, University of CaliforniaSimons FoundationHuman Genome Sequencing Center, Baylor College of MedicineDepartment of Psychiatry, University of MinnesotaVanderbilt Kennedy Center, Vanderbilt University Medical CenterSimons FoundationDepartment of Psychiatry, University of MinnesotaDepartment of Pediatrics, University of Mississippi Medical CenterSimons FoundationDepartment of Psychiatry and Biobehavioral Sciences, University of CaliforniaCenter for Autism and Related Disorders, Kennedy Krieger InstituteHuman Genome Sequencing Center, Baylor College of MedicineSimons FoundationDepartment of Systems Biology, Columbia UniversityHugo W. Moser Research Institute at Kennedy KriegerDepartment of Pediatrics, University of Mississippi Medical CenterDepartment of Pediatrics, Vanderbilt University Medical CenterDepartment of Molecular and Medical Genetics, Oregon Health & Science UniversityCenter for Autism and Related Disorders, Kennedy Krieger InstituteSimons FoundationDepartment of Systems Biology, Columbia UniversitySimons FoundationHuman Genome Sequencing Center, Baylor College of MedicineDepartment of Psychiatry, Columbia University Medical CenterSimons FoundationDepartment of Pediatrics, University of MinnesotaDepartment of Psychiatry, University of MinnesotaDivision of Pediatric Psychology and Neuropsychology, Nationwide Children?ˉs HospitalSimons FoundationDepartment of Molecular and Medical Genetics, Oregon Health & Science UniversityDepartment of Psychiatry and Behavioral Neuroscience, Cincinnati Children?ˉs Hospital Medical Center - Research FoundationDepartment of Molecular and Human Genetics, Baylor College of MedicineHuman Genome Sequencing Center, Baylor College of MedicineMaine Medical Center Research InstituteHuman Development & Family Studies, Colorado State UniversityDepartment of Psychiatry and Biobehavioral Sciences, University of CaliforniaSimons FoundationHuman Genome Sequencing Center, Baylor College of MedicineDepartment of Systems Biology, Columbia UniversityDepartment of Molecular and Medical Genetics, Oregon Health & Science UniversityPreventionGeneticsDepartment of Psychiatry and Behavioral Sciences, University of WashingtonDepartment of Psychiatry, University of MinnesotaDepartment of Psychology, University of MiamiDepartment of Neurology, University of CaliforniaDepartment of Psychiatry and Biobehavioral Sciences, University of CaliforniaDepartment of Molecular and Human Genetics, Baylor College of MedicineVanderbilt Kennedy Center, Vanderbilt University Medical CenterDepartment of Psychology, University of MiamiDepartment of Psychiatry, University of Iowa Carver College of MedicineDepartment of Systems Biology, Columbia UniversityDepartment of Genome Sciences, University of Washington School of MedicineDepartment of Psychiatry, University of Iowa Carver College of MedicineDepartment of Molecular and Human Genetics, Baylor College of MedicineMIND Institute and Department of Psychiatry and Behavioral Sciences, University of CaliforniaDepartment of Genome Sciences, University of Washington School of Medicine||University of Washington, Howard Hughes Medical InstituteDepartment of Molecular and Human Genetics, Baylor College of MedicineDepartment of Psychiatry and Behavioral Neuroscience, Cincinnati Children?ˉs Hospital Medical Center - Research FoundationDepartment of Psychiatry, Weill Cornell MedicineMIND Institute and Department of Psychiatry and Behavioral Sciences, University of CaliforniaPreventionGeneticsDepartment of Psychiatry, University of Iowa Carver College of MedicineDepartment of Psychiatry and Biobehavioral Sciences, University of CaliforniaDepartment of Psychiatry, Weill Cornell MedicineDepartment of Molecular and Human Genetics, Baylor College of MedicineDepartment of Psychiatry and Behavioral Neuroscience, Cincinnati Children?ˉs Hospital Medical Center - Research FoundationDepartment of Psychiatry and Behavioral Sciences, Vanderbilt University Medical CenterSimons FoundationDepartment of Systems Biology, Columbia UniversityDepartment of Psychiatry and Behavioral Sciences, Emory Autism Center, Emory UniversityDepartment of Systems Biology, Columbia UniversityDepartment of Systems Biology, Columbia UniversityDepartment of Psychiatry and Behavioral Sciences, University of WashingtonDepartment of Pediatrics, Boston Children?ˉs HospitalDepartment of Psychiatry, Weill Cornell MedicineDepartment of Psychiatry, University of MinnesotaDepartment of Psychiatry and Behavioral Sciences, Emory Autism Center, Emory UniversitySimons FoundationDepartment of Psychiatry, University of North Carolina at Chapel HillDepartment of Psychology, University of MiamiDepartment of Health Psychology, University of Missouri||Thompson Center for Autism and Neurodevelopmental Disorders, University of MissouriDepartment of Neurosciences, University of California, San Diego, School of MedicineSimons FoundationPreventionGeneticsDepartment of Molecular and Medical Genetics, Oregon Health & Science UniversityDepartment of Psychiatry and Behavioral Neuroscience, Cincinnati Children?ˉs Hospital Medical Center - Research FoundationCenter for Autism and Related Disorders, Kennedy Krieger InstituteDepartment of Medicine, Boston Childrens HospitalDivision of Pediatric Psychology and Neuropsychology, Nationwide Children?ˉs HospitalSimons FoundationDepartment of Psychiatry, University of North Carolina at Chapel HillDepartment of Genome Sciences, University of Washington School of MedicineDepartment of Pediatrics, Baylor College of MedicineDepartment of Psychiatry, Rush University Medical CenterDepartment of Psychiatry, Oregon Health & Science UniversityDepartment of Pediatrics, University of CaliforniaSimons FoundationDepartment of Psychiatry, University of Iowa Carver College of MedicineTranslational Neuroscience Center, Boston Children?ˉs HospitalDepartment of Psychiatry, Rush University Medical CenterCenter for Autism Research, Children?ˉs Hospital of PhiladelphiaCenter for Autism and Related Disorders, Kennedy Krieger InstituteSimons FoundationHuman Genome Sequencing Center, Baylor College of MedicineDepartment of Pediatrics, Boston Children?ˉs HospitalGreenwood Genetic CenterDepartment of Pediatrics, University of Colorado School of MedicineSimons FoundationDepartment of Psychiatry and Behavioral Sciences, Emory Autism Center, Emory UniversityDepartment of Pediatrics, University of Colorado School of MedicineDepartment of Psychiatry, Rush University Medical CenterDepartment of Psychiatry and Biobehavioral Sciences, University of CaliforniaVanderbilt Kennedy Center, Vanderbilt University Medical Center
神经病学、精神病学医学研究方法遗传学
Albright Charles,O?ˉBrien Kaela,Daniels Amy M.,Clark Renee D.,Rosenberg Cordelia R.,Sahin Mustafa,Salomatov Andrei,Thomas Carrie,Schultz Robert T.,Schweers Kathryn A.,Shah Swapnil,Shen Yufeng,Shocklee Amanda D.,Takahashi Nicole,Simon Laura,Stephens Alexandra N.,Smith Kaitlin,Vernoia Brianna M.,Volfovsky Natalia,Wallace Jermel,Walston Corrie H.,Wang Tianyun,White Loran Casey,Wodka Ericka L.,Xu Simon,Yang Wha S.,Yinger Meredith,Zaydens Hana,Zhou Xueya,Astrovskaya Irina,Bardett Nicole,Berry-Kravis Elizabeth,Brueggeman Leo,Butter Eric M.,Callahan Kristen,Cartner Lindsey A.,Chatha Ahmad S.,Chung Wendy K.,Marini Richard,Mason Andrew,Tjernagel Jennifer,Huang-Storms Lark Y.,Hutter Hanna,Jensen William,Jordy Michelle,Juarez A. Pablo,Kaplan Hannah E.,Kent Matt,Korchina Viktoriya,Krentz Anthony D.,Schneider Hoa Lam,Lawson Noah,Layman Kevin,Lee Sandra,Martin Christa Lese,Li Hai,Lord Catherine,Zhou Xueya,Turner Tychele N.,Wang Tianyun,Snyder LeeAnne Green,Muzny Donna M.,The SPARK Consortium,Volfovsky Natalia,Shen Yufeng,Chung Wendy K.,Abbeduto Leonard,Ace Andrea J.,Amaral David G.,Amatya Alpha,Annett Robert D.,Grosvenor Luke P.,Gulsrud Amanda C.,Hall Jacob B.,Han Bing,Hauf Brenda,Hayes Caitlin,Herbert Lynette M.,Horner Susannah,Cohen Cheryl,Courchesne Eric,Currin Mary Hannah,DeMarco Lindsey,Dennis Megan Y.,Ding Yan,Dinh Huyen,Doan Ryan,Doddapaneni HarshaVardhan,Eichler Evan E.,Eng Christine,Feliciano Pamela,Francis Sunday,Ganesan Swami,Gerdts Jennifer A.,Goin-Kochel Robin P.,J.Griswold Anthony,Feliciano Pamela,Nicholson Amy,Ochoa-Lubinoff Cesar,Orobio Jessica,Ousley Opal Y.,Pandey Juhi,Piven Joseph,Pramparo Tiziano,Prock Lisa M.,Rachubinski Angela L.,McKenzie Alexander P.,Morrier Michael J.,Murali Shwetha,Neely Jason,Nessner Caitlin,Ruzzo Elizabeth,Lechniak Holly,Soucy Aubrie,Sutcliffe James S.,Marzano Gabriela,Koomar Tanner,Hilscher Brittani A.,Thomas Taylor,Bashar Asif,Gibbs Richard A.,Hamer Kira E.,Coury Daniel Lee,Pacheco Lillian D.,Garrett Michael,Carriero Nicholas,Smith Christopher J.,Eldred Sara,Russo-Ponsaran Nicole,Jones Mark,Acampado John,Sandhu Sophia,O?ˉConnor Eirene,Rajbhandari Kshitij,Gunderson Jaclyn,Swanson Amy,Robertson Beverly E.,Lillie Natasha,White Sabrina,Mallardi Malcolm D.,Camba Alexies,Singh Vini,Liu Xiuping,Snyder LeeAnne G.,Qi Hongjian,Law J. Kiely,Sarver Dustin E.,Warren Zachary,Barnard Rebecca,Fatemi Ali,Chin Wubin,Zhang Haicang,Stock Colleen M.,Zang Lan,Veenstra-Vanderweele Jeremy,Remington Rick,Esler Amy,Istephanous Dalia,Hanna Nathan,Brooks Elizabeth,Barnard Rebecca A.,Manning Patricia,Gibbs Richard A.,Momin Zeineen,Santangelo Susan,Hepburn Susan L.,Tafolla Maira,Lash Alex E.,Hu Jianhong,Hsieh Alexander,O?ˉRoak Brian J.,Popp Marc,Fox Emily A.,Jacob Suma,Gutierrez Anibal,Geschwind Daniel H.,McCracken James T.,Sabo Aniko,Harris Nina,Alessandri Michael,Brueggeman Leo,Kitaygorodsky Alex,Turner Tychele N.,Michaelson Jacob J.,Muzny Donna,Li Deana,Eichler Evan E.,Beaudet Arthur,Harkins Christina,Qiu Shanping,Thompson Samantha,Fischer Gregory,Michaelson Jacob J.,Haley Monica,Paolicelli Anna Marie,Sabo Aniko,Booker Stephanie,Sutcliffe James S.,Fisk Ian,Hsieh Alexander,Rice Catherine E.,Wang Jiayao,Zhao Haoquan,Bernier Raphael A.,Matthews Emily T.,Heyman Michelle,Wasserburg Lucy,Cubells Joseph F.,Rana Rishiraj,Dichter Gabriel S.,Hale Melissa N.,Kanne Stephen,Pierce Karen L.,Manoharan Julie,Gruber Angela J.,O?ˉRoak Brian J.,Erickson Craig A.,Metre Bonnie Van,Yu Timothy,Scherr Jessica,Astrovskaya Irina,Lamarche Elena,Geisheker Madeleine R.,Simon Andrea R.,Beeson Landon,Fombonne Eric J.,Gazestani Vahid,Butler Martin E.,Bahl Ethan,Brewster Stephanie J.,Lee Soo J.,Plate Samantha,Landa Rebecca J.,Myers Vincent J.,Balasubramanian Adithya,Pawlowski Katherine G.,Skinner Steve,Friedman Sandra L.,Rigby Chris,Roeder Katherine,Shaikh Tamim,Soorya Latha V.,Arriaga Ivette,Carpenter Sarah.Exome sequencing of 457 autism families recruited online provides evidence for novel ASD genes[EB/OL].(2025-03-28)[2025-05-05].https://www.biorxiv.org/content/10.1101/516625.点此复制
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