Neurobehavioural characterisation and stratification of reinforcement-related behaviour
Neurobehavioural characterisation and stratification of reinforcement-related behaviour
Abstract: Reinforcement-related cognitive processes, such as reward processing, impulsiveness and emotional processing are critical components of externalising and internalising behaviours. It is unclear to what extent each of these processes contributes to individual behavioural symptoms, how their neural substrates give rise to distinct behavioural outcomes, and if neural profiles across different reinforcement-related processes might differentiate individual behaviours. We created a statistical framework that enabled us to directly compare functional brain activation during reward anticipation, motor inhibition and viewing of emotional faces in the European IMAGEN cohort of 2000 14-year-old adolescents. We observe significant correlations and modulation of reward anticipation and motor inhibition networks in hyperactivity, impulsivity, inattention and conduct symptoms, and describe neural signatures across neuroimaging tasks that differentiate these behaviours. We thus characterise shared and distinct functional brain activation patterns that underlie different externalising symptoms and identify neural stratification markers, while accounting for clinically observed co-morbidity.
Ing Alex、Jia Tianye、Walter Henrik、IMAGEN Consortium、Tay Nicole、Francesca Biondo、B¨1chel Christian、Desrivi¨¨res Sylvane、Flor Herta、Grigis Antoine、Garavan Hugh、Gowland Penny、Heinz Andreas、Martinot Marie-Laure Paill¨¨re、Nees Frauke、Fr?hner Juliane H.、Martinot Jean-Luc、Luo Qiang、Schumann Gunter、Paus Tom¨￠?、Smolka Michael N.、Ittermann Bernd、Quinlan Erin Burke、Bromberg Uli、Bokde Arun L.W.、Whelan Robert、Orfanos Dimitri Papadopoulos、Barker Gareth J.、Banaschewski Tobias、Poustka Luise、Feng Jianfeng
神经病学、精神病学生物科学研究方法、生物科学研究技术基础医学
Ing Alex,Jia Tianye,Walter Henrik,IMAGEN Consortium,Tay Nicole,Francesca Biondo,B¨1chel Christian,Desrivi¨¨res Sylvane,Flor Herta,Grigis Antoine,Garavan Hugh,Gowland Penny,Heinz Andreas,Martinot Marie-Laure Paill¨¨re,Nees Frauke,Fr?hner Juliane H.,Martinot Jean-Luc,Luo Qiang,Schumann Gunter,Paus Tom¨￠?,Smolka Michael N.,Ittermann Bernd,Quinlan Erin Burke,Bromberg Uli,Bokde Arun L.W.,Whelan Robert,Orfanos Dimitri Papadopoulos,Barker Gareth J.,Banaschewski Tobias,Poustka Luise,Feng Jianfeng.Neurobehavioural characterisation and stratification of reinforcement-related behaviour[EB/OL].(2025-03-28)[2025-05-05].https://www.biorxiv.org/content/10.1101/778308.点此复制
评论