Interleukin 1 beta is associated with depression in Multiple Sclerosis patients
Interleukin 1 beta is associated with depression in Multiple Sclerosis patients
Abstract Depressive and anxiety symptoms occur more frequently in chronic encephalomyelitis. Inflammatory diseases are highly associated with psychiatric comorbidities, which has been well established in Multiple Sclerosis. However, no biomarkers have been found with the capacity to discern between MS and depression. Thirty-six individuals with a diagnosis of MS according to the revised McDonald criteria, were recruited from an outpatient Neurology and Psychiatry from the medical unit of high specialty in Mexico. We measured the association between BDNF, IL-1β, and TNFα in serum with the presence of depression and anxiety using the semi-structured psychiatric interview, the Beck Depression Inventory (IDB), and Hospital Anxiety and Depression Scale (HADS). This was a cross-sectional study. The Logistic Regression was used for the multivariate analysis adjusted by the Multiple Sclerosis Severity Score (MSSS). With a power of 0.75 in the final model, patients with multiple sclerosis, depression, and anxiety obtained the highest values of IL-1 β in our study.
Islas-Hernandez Azul、Corlay-Noriega Irma、Garcia-delaTorre Paola、Aguilar-Talamantes Hugo、Bertado-Cort¨|s Brenda、Rodriguez-Casta?enda Aleida
Unidad de Investigaci¨?n M¨|dica en Enfermedades Neurol¨?gicas, Hospital de Especialidades, CMN SXXI, Instituto Mexicano del Seguro Social||Posgrado en Ciencias Biol¨?gicas, Universidad Nacional Aut¨?noma de M¨|xicoServicio de Psiquiatr¨aa, Hospital de Especialidades, CMN SXXI, Instituto Mexicano del Seguro SocialUnidad de Investigaci¨?n M¨|dica en Enfermedades Neurol¨?gicas, Hospital de Especialidades, CMN SXXI, Instituto Mexicano del Seguro SocialHospital Psiqui¨￠trico H¨|ctor Tovar Acosta, Instituto Mexicano del Seguro SocialServicio de Neurolog¨aa, Hospital de Especialidades, CMN SXXI, Instituto Mexicano del Seguro SocialUnidad de Investigaci¨?n M¨|dica en Enfermedades Neurol¨?gicas, Hospital de Especialidades, CMN SXXI, Instituto Mexicano del Seguro Social
神经病学、精神病学基础医学医学研究方法
Islas-Hernandez Azul,Corlay-Noriega Irma,Garcia-delaTorre Paola,Aguilar-Talamantes Hugo,Bertado-Cort¨|s Brenda,Rodriguez-Casta?enda Aleida.Interleukin 1 beta is associated with depression in Multiple Sclerosis patients[EB/OL].(2025-03-28)[2025-04-30].https://www.medrxiv.org/content/10.1101/2020.12.11.20245472.点此复制
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