DNA methylation in the APOE gene: its link with Alzheimer’s and cardiovascular health
DNA methylation in the APOE gene: its link with Alzheimer’s and cardiovascular health
Abstract Genetic variation in the apolipoprotein E (APOE) gene is associated with Alzheimer’s disease (AD) and risk factors for cardiovascular disease (CVD). DNA methylation at APOE has been linked to altered cognition and AD. It is unclear if epigenetic marks could be used for predicting future disease. We assessed blood-based DNA methylation at 13 CpGs in the APOE gene in 5828 participants from the Generation Scotland (GS) cohort. Using linear regression, we examined the relationship between APOE methylation, cognition, cholesterol, and the risks for AD and CVD. DNA methylation at two CpGs was associated with the ratio of total-to-HDL cholesterol, but not with cognition, or the risks of AD or CVD. APOE methylation could be involved in the levels of blood cholesterol, but there is no evidence for the utility of APOE methylation as a biomarker for predicting AD or CVD.
McCartney Daniel L.、Bermingham Mairead L.、Evans Kathryn L.、Marioni Riccardo E.、Morris Stewart W.、Walker Rosie M.、Porteous David J.、Mur Jure、McIntosh Andrew M.、Deary Ian J.、Campbell Archie
Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of EdinburghCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of EdinburghCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of EdinburghCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of EdinburghCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of EdinburghCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of EdinburghCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of EdinburghDepartment of Psychology, University of Edinburgh||Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of EdinburghCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh||Division of Psychiatry, Centre for Clinical Brain Sciences, University of EdinburghDepartment of Psychology, University of EdinburghCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh
基础医学神经病学、精神病学遗传学
McCartney Daniel L.,Bermingham Mairead L.,Evans Kathryn L.,Marioni Riccardo E.,Morris Stewart W.,Walker Rosie M.,Porteous David J.,Mur Jure,McIntosh Andrew M.,Deary Ian J.,Campbell Archie.DNA methylation in the APOE gene: its link with Alzheimer’s and cardiovascular health[EB/OL].(2025-03-28)[2025-05-05].https://www.biorxiv.org/content/10.1101/811224.点此复制
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