Multi-ancestry GWAS of major depression aids locus discovery, fine-mapping, gene prioritisation, and causal inference
McQuillin Andrew 1van Heel David A. 2Meng Xiangrui 1Navoly Georgina 3Koller Dora 4Renter¨aa Miguel E. 5Gaziano J. Michael 6Zar Heather J. 7Campbell Megan L. 8Finer Sarah 9Bass Nick 1Martin Hilary 10Chen Hsi-Chung 11Tsai Shih-Jen 12Kendler Kenneth S. 13Fang Yu 14Sen Srijan 15Scott Laura 16Loos Ruth 17Preuss Michael 18Actkins Ky?ˉEra V. 19the 23andMe Research Team Dunn Erin C. 20Davis Lea K. 21Uddin Monica 22Ursano Robert J. 23Rabinowitz Jill 24Uhl George 25Eaton William 24Cruz-Fuentes Carlos S. 26Martinez-Levy Gabriela A. 26Wassertheil-Smoller Sylvia 27Martin Nicholas G. 28Okada Yukinori 29Gelernter Joel 30Lin Kuang 31Kuchenbaecker Karoline 32Maher Brion 24Feng Yanzhe 1Kanai Masahiro 33Jiang Yunxuan 34Trivedi Bhavi 2Genes & Health Research Team Valkovskaya Maria 1Awasthi Swapnil 35Peterson Roseann E. 36Byrne Enda M. 37Giannakopoulou Olga 1Walters Robin G. 38Cai Na 39Mitchell Brittany L. 28Koen Nastassja 7Pathak Gita 40Sofer Tamar 41Wani Agaz 22Liu Yu-Li 42Burmeister Margit 43Chundru V. Kartik 10Wildman Derek 22Stein Murray B. 44Wray Naomi R. 45PGC MDD Working Group Sakaue Saori 46Lewis Cathryn 47Kessler Ronald C. 48Kuo Po-Hsiu 49China Kadoorie Biobank Collaborative Group Tian Chao 50Ripke Stephan 51Huang Qin Qin 10Coleman Jonathan R. I. 52Stein Dan J. 7Polimanti Renato 53Levey Daniel 54Campos Adrian I. 55Li Liming 56Millwood Iona Y. 38Chen Zhengming38
作者信息
- 1. Division of Psychiatry, UCL
- 2. Blizard Institute, Queen Mary University of London
- 3. UCL Genetics Institute, UCL
- 4. Department of Psychiatry, Yale University School of Medicine||Department of Genetics, Microbiology and Statistics, University of Barcelona||VA CT Healthcare Center
- 5. Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute
- 6. Department of Medicine, VA Boston Healthcare System||Department of Medicine, Brigham and Women?ˉs Hospital||Department of Medicine, Harvard Medical School
- 7. SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute, University of Cape Town
- 8. Department of Psychiatry and Neuroscience Institute
- 9. Wolfson Institute of Population Health, Queen Mary University of London
- 10. Wellcome Sanger Institute
- 11. Department of Psychiatry, National Taiwan University Hospital||Center of Sleep Disorders, National Taiwan University Hospital
- 12. Institute of Brain Science & Division of Psychiatry, National Yang-Ming Chiao Tung University||Department of Psychiatry, Taipei Veterans General Hospital
- 13. Department of Psychiatry
- 14. Michigan Neuroscience Institute, University of Michigan
- 15. Michigan Neuroscience Institute, University of Michigan||Department of Psychiatry, University of Michigan
- 16. Department of Biostatistics, University of Michigan
- 17. Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai||Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen
- 18. Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai
- 19. Department of Medicine, Vanderbilt University Medical Center
- 20. Department of Psychiatry, Massachusetts General Hospital||Psychiatric and Neurodevelopmental Genetics Unit (PNGU)||Stanley Center for Psychiatric Research, Broad Institute
- 21. Department of Medicine, Division of Genetic Medicine, Vanderbilt University Medical Center||Department of Biomedical Informatics, Vanderbilt University Medical Center||Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center
- 22. College of Public Health, University of South Florida
- 23. Department of Psychiatry, Uniformed Services University of the Health Sciences
- 24. Department of Mental Health, Johns Hopkins University Bloomberg School of Public Health
- 25. Neurology and Pharmacology, University of Maryland, Maryland VA Healthcare System
- 26. Departamento de Gen¨|tica, Instituto Nacional de Psiquiatr¨aa ?°Ram¨?n de la Fuente Mu?¨az?±
- 27. Department of Epidemiology and Population Health Albert Einstein College of Medicine
- 28. Mental Health and Neuroscience Research Program, QIMR Berghofer Medical Research Institute
- 29. Department of Statistical Genetics, Osaka University Graduate School of Medicine||Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo||Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences
- 30. Department of Psychiatry, VA CT Healthcare Center||Department of Psychiatry, Yale University School of Medicine||Department of Genetics, Yale University School of Medicine
- 31. Nuffield Department of Population Health, University of Oxford
- 32. Division of Psychiatry, UCL||UCL Genetics Institute, UCL
- 33. Department of Statistical Genetics, Osaka University Graduate School of Medicine||Analytic and Translational Genetics Unit, Massachusetts General Hospital Boston||Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
- 34. Department of Biostatistic, Emory University||23andMe, Inc.
- 35. Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT
- 36. Department of Psychiatry||Department of Psychiatry, SUNY Downstate Health Sciences University
- 37. Institute for Molecular Bioscience, The University of Queensland||Child Health Research Centre, The University of Queensland
- 38. Nuffield Department of Population Health, University of Oxford||MRC Population Health Research Unit, University of Oxford
- 39. Helmholtz Pioneer Campus
- 40. Department of Psychiatry, Yale University School of Medicine||VA CT Healthcare Center
- 41. Division of Sleep and Circadian Disorders, Department of Medicine Brigham and Women?ˉs Hospital||Department of Biostatistics, Harvard T.H. Chan School of Public Health
- 42. Center for Neuropsychiatric Research, National Health Research Institutes
- 43. Michigan Neuroscience Institute, University of Michigan||Department of Psychiatry, University of Michigan||Department of Computational Medicine & Bioinformatics, University of Michigan||Department of Human Genetics, University of Michigan
- 44. Department of Psychiatry, UC San Diego School of Medicine||Department of Public Health, UC San Diego School of Medicine, School of Public Health||Department of Psychiatry, VA San Diego Healthcare System
- 45. Institute for Molecular Bioscience, The University of Queensland||Queensland Brain Institute, The University of Queensland
- 46. Department of Statistical Genetics, Osaka University Graduate School of Medicine||Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women?ˉs Hospital, Harvard Medical School||Program in Medical and Population Genetics, Broad Institute of Harvard and MIT
- 47. Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology||Department of Medical & Molecular Genetics, King?ˉs College London
- 48. Health Care Policy, Harvard Medical School
- 49. Department of Public Health & Institute of Epidemiology and Preventive Medicine, National Taiwan University||Department of Psychiatry, National Taiwan University Hospital
- 50. University of California - Davis||23andMe, Inc.
- 51. Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT||Analytic and Translational Genetics Unit, Massachusetts General Hospital||Department of Psychiatry and Psychotherapy, Charit¨| - Universit?tsmedizin
- 52. Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology||Neuroscience, King?ˉs College London
- 53. Department of Psychiatry, Yale University School of Medicine||VA CT Healthcare Center||VA Connecticut Healthcare Center
- 54. Department of Psychiatry, VA CT Healthcare Center||Department of Psychiatry, Yale University School of Medicine
- 55. Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute||Institute of Molecular Bioscience, The University of Queensland
- 56. Department of Epidemiology and Biostatistics, School of Public Health, Peking University||Peking University Center for Public Health and Epidemic Preparedness & Response, Peking University
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McQuillin Andrew,van Heel David A.,Meng Xiangrui,Navoly Georgina,Koller Dora,Renter¨aa Miguel E.,Gaziano J. Michael,Zar Heather J.,Campbell Megan L.,Finer Sarah,Bass Nick,Martin Hilary,Chen Hsi-Chung,Tsai Shih-Jen,Kendler Kenneth S.,Fang Yu,Sen Srijan,Scott Laura,Loos Ruth,Preuss Michael,Actkins Ky?ˉEra V.,the 23andMe Research Team,Dunn Erin C.,Davis Lea K.,Uddin Monica,Ursano Robert J.,Rabinowitz Jill,Uhl George,Eaton William,Cruz-Fuentes Carlos S.,Martinez-Levy Gabriela A.,Wassertheil-Smoller Sylvia,Martin Nicholas G.,Okada Yukinori,Gelernter Joel,Lin Kuang,Kuchenbaecker Karoline,Maher Brion,Feng Yanzhe,Kanai Masahiro,Jiang Yunxuan,Trivedi Bhavi,Genes & Health Research Team,Valkovskaya Maria,Awasthi Swapnil,Peterson Roseann E.,Byrne Enda M.,Giannakopoulou Olga,Walters Robin G.,Cai Na,Mitchell Brittany L.,Koen Nastassja,Pathak Gita,Sofer Tamar,Wani Agaz,Liu Yu-Li,Burmeister Margit,Chundru V. Kartik,Wildman Derek,Stein Murray B.,Wray Naomi R.,PGC MDD Working Group,Sakaue Saori,Lewis Cathryn,Kessler Ronald C.,Kuo Po-Hsiu,China Kadoorie Biobank Collaborative Group,Tian Chao,Ripke Stephan,Huang Qin Qin,Coleman Jonathan R. I.,Stein Dan J.,Polimanti Renato,Levey Daniel,Campos Adrian I.,Li Liming,Millwood Iona Y.,Chen Zhengming.Multi-ancestry GWAS of major depression aids locus discovery, fine-mapping, gene prioritisation, and causal inference[EB/OL].(2025-03-28)[2025-12-14].https://www.biorxiv.org/content/10.1101/2022.07.20.500802.学科分类
医学研究方法/基础医学/神经病学、精神病学
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