Genes associated with depression and coronary artery disease are enriched for inflammation and cardiomyopathy-associated pathways
Genes associated with depression and coronary artery disease are enriched for inflammation and cardiomyopathy-associated pathways
Abstract BackgroundDepression and Coronary Artery Disease (CAD) are highly comorbid conditions. Approximately 40% of individuals who have one diagnosis will also develop the other within their lifetime. Prior research indicates that polygenic risk for depression increases the odds of developing CAD even in the absence of clinical depression. However, the specific genes and pathways involved in comorbid depression-CAD remain unknown. ResultsWe identified genes that are significantly associated with both depression and CAD, and are enriched for pathways involved in inflammation and for previous association with cardiomyopathy. We observed increased rate of prevalent, but not incident, cardiomyopathy cases in individuals with comorbid depression-CAD compared to those with CAD alone in three electronic large health record (EHR) datasets. ConclusionsThe results of our study implicate genetically regulated inflammatory mechanisms in depression-CAD. Our results also raise the hypothesis that depression-associated CAD may be enriched for cardiomyopathy. Clinical PerspectiveWhat’s New?Gene associations shared between depression and CAD are enriched for prior association with cardiomyopathy phenotypes.Cardiomyopathy is significantly more prevalent in individuals with comorbid depression-CAD than in CAD or depression alone.What are the Clinical Implications?Our work suggests that individuals with comorbid depression-CAD may benefit from screening for cardiomyopathy.
Sealock Julia M、Straub Peter、Cox Nancy J.、Wells Quinn S.、Hodges Emily C.、Singh Kritika、Miller-Flemming Tyne、Smoller Jordan M.、Davis Lea K.、Lee Hyunjoon
Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center||Vanderbilt Genetics Institute, Vanderbilt University Medical CenterDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center||Vanderbilt Genetics Institute, Vanderbilt University Medical CenterDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center||Vanderbilt Genetics Institute, Vanderbilt University Medical CenterDivision of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical CenterVanderbilt Genetics Institute, Vanderbilt University Medical Center||Department of Biochemistry, Vanderbilt University School of MedicineDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center||Vanderbilt Genetics Institute, Vanderbilt University Medical CenterDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center||Vanderbilt Genetics Institute, Vanderbilt University Medical CenterPsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital||Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital||Stanley Center for Psychiatric Research, Broad Institute of Harvard and MITDivision of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center||Vanderbilt Genetics Institute, Vanderbilt University Medical Center||Department of Molecular Physiology and Biophysics, Vanderbilt University Medical Center||Department of Psychiatry and Behavioral Sciences, Vanderbilt University Medical Center||Departments of Medicine and Biomedical Informatics, Vanderbilt University Medical CenterPsychiatric and Neurodevelopmental Genetics Unit, Center for Genomic Medicine, Massachusetts General Hospital||Center for Precision Psychiatry, Department of Psychiatry, Massachusetts General Hospital||Stanley Center for Psychiatric Research, Broad Institute of Harvard and MIT
医药卫生理论医学研究方法内科学
Sealock Julia M,Straub Peter,Cox Nancy J.,Wells Quinn S.,Hodges Emily C.,Singh Kritika,Miller-Flemming Tyne,Smoller Jordan M.,Davis Lea K.,Lee Hyunjoon.Genes associated with depression and coronary artery disease are enriched for inflammation and cardiomyopathy-associated pathways[EB/OL].(2025-03-28)[2025-05-25].https://www.medrxiv.org/content/10.1101/2022.10.25.22280854.点此复制
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