Titan mice are a unique bred mammalian model to study obesity and aspects of metabolic syndrome
Imhof Axel 1Sanz-Moreno Adri¨￠n 2Venkatasubramani Anuroop Venkateswaran 1Langhammer Martina 3Aguilar-Pimentel Antonio 2Klein-Rodewald Tanja 2Calzada-Wack Julia 2Meng Chen 4Koch Franziska 5Gailus-Durner Valerie 2Peleg Shahaf 6Rathkolb Birgit 7Brenmoehl Julia 8Fuchs Helmut 2Becker Lore 2de Angelis Martin Hrabe 9Caton Vanessa 8Ludwig Christina 4Gerlini Raffaele 10de-Diego Irene 6M¨1ller-Eigner Annika 6Kuhla Angela 11Hoeflich Andreas8
作者信息
- 1. Department of Molecular Biology, Biomedical Center Munich, Ludwig-Maximilians University
- 2. German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum M¨1nchen, German Research Center for Environment and Health (GmbH)
- 3. Institute Genetics and Biometry, Lab Animal Facility, Leibniz Institute for Farm Animal Biology
- 4. Bavarian Center for Biomolecular Mass Spectrometry, Technical University of Munich
- 5. Institute of Nutritional Physiology, Leibniz Institute for Farm Animal Biology
- 6. Research Group Epigenetics, Metabolism and Longevity, Leibniz Institute for Farm Animal Biology
- 7. German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum M¨1nchen, German Research Center for Environment and Health (GmbH)||German Center for Diabetes Research (DZD)||Institute of Molecular Animal Breeding and Biotechnology, Gene Center, Ludwig-Maximilians-University Munich
- 8. Institute for Genome Biology, Leibniz Institute for Farm Animal Biology
- 9. German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum M¨1nchen, German Research Center for Environment and Health (GmbH)||German Center for Diabetes Research (DZD)||Chair of Experimental Genetics, TUM School of Life Sciences (SoLS), Technische Universit?t M¨1nchen
- 10. German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum M¨1nchen, German Research Center for Environment and Health (GmbH)||German Center for Diabetes Research (DZD)
- 11. Institute for Experimental Surgery, Rostock University Medical Center
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Abstract
Abstract
Obesity is a major culprit for metabolic syndrome (MetS). Relevant animal models can promote translational research on metabolic disorders. In this study, we suggest the Titan mouse as a new model for obesity and MetS. We show that adult Titan mice display several characteristics of MetS, including obesity and increased plasma levels of leptin, FGF21, insulin, cholesterol and triglycerides. This metabolic phenotype correlated with ectopic fat infiltration in the pancreas, ‘whitening’ of brown adipose tissue, increased inflammatory markers (IL-6, TNFα) and nodular thymic medullary hyperplasia. Liver transcriptomics and proteomics demonstrated alterations in lipid and sulfur metabolism, and in xenobiotic metabolic regulation. Interestingly, late dietary intervention in Titan mice reduced fat content, altered the expression of genes involved in lipid synthesis and cytochrome P450 detoxification, improved plasma health metrics and increased lifespan. Altogether, we propose the Titan mice as a powerful model for translational research and intervention on obesity and MetS.引用本文复制引用
Imhof Axel,Sanz-Moreno Adri¨￠n,Venkatasubramani Anuroop Venkateswaran,Langhammer Martina,Aguilar-Pimentel Antonio,Klein-Rodewald Tanja,Calzada-Wack Julia,Meng Chen,Koch Franziska,Gailus-Durner Valerie,Peleg Shahaf,Rathkolb Birgit,Brenmoehl Julia,Fuchs Helmut,Becker Lore,de Angelis Martin Hrabe,Caton Vanessa,Ludwig Christina,Gerlini Raffaele,de-Diego Irene,M¨1ller-Eigner Annika,Kuhla Angela,Hoeflich Andreas.Titan mice are a unique bred mammalian model to study obesity and aspects of metabolic syndrome[EB/OL].(2025-03-28)[2026-05-01].https://www.biorxiv.org/content/10.1101/2020.05.11.088625.学科分类
基础医学/生物科学研究方法、生物科学研究技术/生理学
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