Negligible impact of SARS-CoV-2 variants on CD4 + and CD8 + T cell reactivity in COVID-19 exposed donors and vaccinees
Negligible impact of SARS-CoV-2 variants on CD4 + and CD8 + T cell reactivity in COVID-19 exposed donors and vaccinees
SUMMARY The emergence of SARS-CoV-2 variants highlighted the need to better understand adaptive immune responses to this virus. It is important to address whether also CD4+ and CD8+ T cell responses are affected, because of the role they play in disease resolution and modulation of COVID-19 disease severity. Here we performed a comprehensive analysis of SARS-CoV-2-specific CD4+ and CD8+ T cell responses from COVID-19 convalescent subjects recognizing the ancestral strain, compared to variant lineages B.1.1.7, B.1.351, P.1, and CAL.20C as well as recipients of the Moderna (mRNA-1273) or Pfizer/BioNTech (BNT162b2) COVID-19 vaccines. Similarly, we demonstrate that the sequences of the vast majority of SARS-CoV-2 T cell epitopes are not affected by the mutations found in the variants analyzed. Overall, the results demonstrate that CD4+ and CD8+ T cell responses in convalescent COVID-19 subjects or COVID-19 mRNA vaccinees are not substantially affected by mutations found in the SARS-CoV-2 variants.
Tarke Alison、Sidney John、Zhang Yun、Goodwin Benjamin、Sutherland Aaron、Rawlings Stephen A.、Peters Bjoern、Smith Davey M.、Frazier April、Dan Jennifer M.、Sette Alessandro、da Silva Antunes Ricardo、Methot Nils、Weiskopf Daniela、Crotty Shane、Rubiro Paul、Scheuermann Richard H.、Grifoni Alba
Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI)||Department of Internal Medicine and Center of Excellence for Biomedical Research (CEBR), University of GenoaCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI)J. Craig Venter InstituteCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI)Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI)Department of Medicine, Division of Infectious Diseases and Global Public Health, University of CaliforniaCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI)||Department of Medicine, Division of Infectious Diseases and Global Public Health, University of CaliforniaDepartment of Medicine, Division of Infectious Diseases and Global Public Health, University of CaliforniaCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI)Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI)||Department of Medicine, Division of Infectious Diseases and Global Public Health, University of CaliforniaCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI)||Department of Medicine, Division of Infectious Diseases and Global Public Health, University of CaliforniaCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI)Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI)Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI)Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI)||Department of Medicine, Division of Infectious Diseases and Global Public Health, University of CaliforniaCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI)Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI)||J. Craig Venter Institute||Department of Pathology, University of CaliforniaCenter for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology (LJI)
基础医学生物科学研究方法、生物科学研究技术微生物学
Tarke Alison,Sidney John,Zhang Yun,Goodwin Benjamin,Sutherland Aaron,Rawlings Stephen A.,Peters Bjoern,Smith Davey M.,Frazier April,Dan Jennifer M.,Sette Alessandro,da Silva Antunes Ricardo,Methot Nils,Weiskopf Daniela,Crotty Shane,Rubiro Paul,Scheuermann Richard H.,Grifoni Alba.Negligible impact of SARS-CoV-2 variants on CD4 + and CD8 + T cell reactivity in COVID-19 exposed donors and vaccinees[EB/OL].(2025-03-28)[2025-04-27].https://www.biorxiv.org/content/10.1101/2021.02.27.433180.点此复制
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