Role of Epigenetics in Unicellular to Multicellular Transition in Dictyostelium
Role of Epigenetics in Unicellular to Multicellular Transition in Dictyostelium
Abstract The evolution of multicellularity is a critical event that remains incompletely understood. We use the social amoeba, Dictyostelium discoideum, one of the rare organisms that exists in both unicellular and multicellular stages, to examine the role of epigenetics in regulating multicellularity. While transitioning to multicellular states, patterns of H3K4 methylation and H3K27 acetylation significantly change. By combining transcriptomics, epigenomics, chromatin accessibility, and syntenic analyses with other unicellular and multicellular organisms, we identify 52 conserved genes, which are specifically accessible and expressed during multicellular states. We validated that four of these genes, including the H3K27 deacetylase hdaD, are necessary and that an SMC-like gene, smcl1, is sufficient for multicellularity. These results highlight the importance of epigenetics in reorganizing chromatin architecture to facilitate the evolution of multicellularity. One Sentence SummaryEpigenetic regulation of multicellularity
Greer Eric Lieberman、Greer Paul Lieberman、Pollina Elizabeth Ann、Fritsche Colette、Takashima Ken、Sabin George、Bushnell Henry L.、Wang I-Hao、Wang Simon Yuan
Division of Newborn Medicine, Boston Children?ˉs Hospital||Department of Pediatrics, Harvard Medical SchoolProgram in Molecular Medicine, University of Massachusetts Medical SchoolDepartment of Neurobiology, Harvard Medical SchoolDivision of Newborn Medicine, Boston Children?ˉs HospitalDivision of Newborn Medicine, Boston Children?ˉs Hospital||Department of Pediatrics, Harvard Medical SchoolDivision of Newborn Medicine, Boston Children?ˉs HospitalDivision of Newborn Medicine, Boston Children?ˉs Hospital||Department of Pediatrics, Harvard Medical SchoolProgram in Molecular Medicine, University of Massachusetts Medical SchoolDivision of Newborn Medicine, Boston Children?ˉs Hospital||Department of Pediatrics, Harvard Medical School
遗传学细胞生物学分子生物学
Greer Eric Lieberman,Greer Paul Lieberman,Pollina Elizabeth Ann,Fritsche Colette,Takashima Ken,Sabin George,Bushnell Henry L.,Wang I-Hao,Wang Simon Yuan.Role of Epigenetics in Unicellular to Multicellular Transition in Dictyostelium[EB/OL].(2025-03-28)[2025-08-02].https://www.biorxiv.org/content/10.1101/2020.09.03.282152.点此复制
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