Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations
Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations
Abstract While tumor genome sequencing has become widely available in clinical and research settings, the interpretation of tumor somatic variants remains an important bottleneck. Most of the alterations observed in tumors, including those in well-known cancer genes, are of uncertain significance. Moreover, the information on tumor genomic alterations shaping the response to existing therapies is fragmented across the literature and several specialized resources. Here we present the Cancer Genome Interpreter (http://www.cancergenomeinterpreter.org), an open access tool that we have implemented to annotate genomic alterations and interpret their possible role in tumorigenesis and in the response to anti-cancer therapies.
Schroeder Michael P、Lopez-Bigas Nuria、Vivancos Ana、Deu-Pons Jordi、Albanell Joan、Torres Carmen de、Gonzalez-Perez Abel、Tabernero Josep、Rubio-Perez Carlota、Rovira Ana、Tusquets Ignasi、Rodon Jordi、Tamborero David、Dienstmann Rodrigo
Research Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University||Charit¨| ¨C Universit?tsmedizin BerlinResearch Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University||Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology||Instituci¨? Catalana de Recerca i Estudis Avan?ats (ICREA)Vall d?ˉHebron Institute of Oncology, Vall d?ˉHebron University Hospital, Autonomous University of BarcelonaResearch Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University||Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and TechnologyMedical Oncology Service, Hospital del Mar Medical Research Institute (IMIM)Developmental Tumor Biology Laboratory, Institut de Recerca Pedi¨¤trica-Hospital Sant Joan de D¨|u BarcelonaResearch Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University||Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and TechnologyVall d?ˉHebron Institute of Oncology, Vall d?ˉHebron University Hospital, Autonomous University of BarcelonaResearch Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra UniversityMedical Oncology Service, Hospital del Mar Medical Research Institute (IMIM)Medical Oncology Service, Hospital del Mar Medical Research Institute (IMIM)||Autonomous University of BarcelonaVall d?ˉHebron Institute of Oncology, Vall d?ˉHebron University Hospital, Autonomous University of BarcelonaResearch Program on Biomedical Informatics (GRIB), IMIM Hospital del Mar Medical, Research Institute and Pompeu Fabra University||Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and TechnologyVall d?ˉHebron Institute of Oncology, Vall d?ˉHebron University Hospital, Autonomous University of Barcelona
肿瘤学生物科学研究方法、生物科学研究技术基础医学
Schroeder Michael P,Lopez-Bigas Nuria,Vivancos Ana,Deu-Pons Jordi,Albanell Joan,Torres Carmen de,Gonzalez-Perez Abel,Tabernero Josep,Rubio-Perez Carlota,Rovira Ana,Tusquets Ignasi,Rodon Jordi,Tamborero David,Dienstmann Rodrigo.Cancer Genome Interpreter annotates the biological and clinical relevance of tumor alterations[EB/OL].(2025-03-28)[2025-06-13].https://www.biorxiv.org/content/10.1101/140475.点此复制
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