Connectivity and Synaptic Physiology in the Mouse and Human Neocortex
Connectivity and Synaptic Physiology in the Mouse and Human Neocortex
Abstract We present a unique, extensive, public synaptic physiology dataset. The dataset contains over 20,000 neuron pairs probed with multipatch using standardized protocols to capture short-term dynamics. Recordings were made in the human temporal cortex and the adult mouse visual cortex. Our main purpose is to offer data and analyses that provide a more complete picture of the cortical microcircuit to the community. We also make several important findings that relate connectivity and synaptic properties to the major cell subclasses and cortical layer via the development of novel analysis methods for quantifying connectivity, synapse properties, and synaptic dynamics. We find that excitatory synaptic dynamics depend strongly on the postsynaptic cell subclass, whereas inhibitory synaptic dynamics depend on the presynaptic cell subclass. Despite these associations, short-term synaptic plasticity is heterogeneous in most subclass to subclass connections. We also find that intralaminar connection probability exhibits a strong layer dependence. In human cortex, we find that excitatory synapses are highly reliable, recover rapidly, and are distinct from mouse excitatory synapses.
Clark Michael、Sunkin Susan、Bomben Jasmine、Hejazinia Nika、Gwinn Ryder P、Dee Nick、Kroll Matthew、Egdorf Tom、Maxwell Michelle、McGraw Medea、Ruiz Augustin、Feng David、Arkhipov Anton、Sorensen Staci、Murphy Gabe、Phillips John、D?ˉOrazi Florence D、Hoggarth Alex、Ito Shinya、Kim Mean-Hwan、Hage Travis、Braun Thomas、Williams Grace、Dotson Nadia、Ransford Shea、Goldy Jeff、McMillen Delissa、Tieu Michael、Ellenbogen Richard、Enstrom Rachel、Chartrand Thomas、Pom Christina Alice、Seeman Stephanie C、Siverts La?ˉAkea、Kim Lisa、Zeng Hongkui、Berry Kyla、Lein Ed、Teeter Corinne、Daigle Tanya L.、Ellingwood Lauren、Farrell Colin、Szafer Aaron、Jarsky Tim、Hupp Madie、Nicovich Rusty、Cobb Charles、Larsen Rachael、Slaughterbeck Cliff、Tasic Bosiljka、Gary Amanda、Ojemann Jeffrey G、Carey Daniel、Bernard Amy、Koch Christof、Walker Miranda、Ngo Kiet、Alfiler Lauren、Campagnola Luke、Potekhina Lydia、Lee Samuel Dingman、Pham Trangthanh、Ko Andrew L、Silbergeld Daniel L、Smith Kimberly、Dalley Rachel、Trinh Jessica、Gorham Melissa、Gloe Jessica、Shi Shu、Schroedter Martin、Gamlin Clare、Wadhwani Katherine、Brouner Krissy、Tung Herman、Casper Tamara、Davoudian Pasha、Sulc Josef、Radaelli Cristina、Wakeman Wayne、Crichton Kirsten、Esposito Luke、Keene C. Dirk
Allen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceEpilepsy Surgery and Functional Neurosurgery, Swedish Neuroscience InstituteAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceByte Physics ()Allen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceDepartment of Neurological Surgery, University of WashingtonAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceThe Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment, Swedish Neuroscience InstituteAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceDepartment of Neurological Surgery, University of Washington||Regional Epilepsy Center at Harborview Medical CenterAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceDepartment of Neurological Surgery, University of Washington||Regional Epilepsy Center at Harborview Medical CenterDepartment of Neurological Surgery, University of WashingtonAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceAllen Institute for Brain ScienceDepartment of Pathology, University of Washington
细胞生物学生理学生物物理学
Clark Michael,Sunkin Susan,Bomben Jasmine,Hejazinia Nika,Gwinn Ryder P,Dee Nick,Kroll Matthew,Egdorf Tom,Maxwell Michelle,McGraw Medea,Ruiz Augustin,Feng David,Arkhipov Anton,Sorensen Staci,Murphy Gabe,Phillips John,D?ˉOrazi Florence D,Hoggarth Alex,Ito Shinya,Kim Mean-Hwan,Hage Travis,Braun Thomas,Williams Grace,Dotson Nadia,Ransford Shea,Goldy Jeff,McMillen Delissa,Tieu Michael,Ellenbogen Richard,Enstrom Rachel,Chartrand Thomas,Pom Christina Alice,Seeman Stephanie C,Siverts La?ˉAkea,Kim Lisa,Zeng Hongkui,Berry Kyla,Lein Ed,Teeter Corinne,Daigle Tanya L.,Ellingwood Lauren,Farrell Colin,Szafer Aaron,Jarsky Tim,Hupp Madie,Nicovich Rusty,Cobb Charles,Larsen Rachael,Slaughterbeck Cliff,Tasic Bosiljka,Gary Amanda,Ojemann Jeffrey G,Carey Daniel,Bernard Amy,Koch Christof,Walker Miranda,Ngo Kiet,Alfiler Lauren,Campagnola Luke,Potekhina Lydia,Lee Samuel Dingman,Pham Trangthanh,Ko Andrew L,Silbergeld Daniel L,Smith Kimberly,Dalley Rachel,Trinh Jessica,Gorham Melissa,Gloe Jessica,Shi Shu,Schroedter Martin,Gamlin Clare,Wadhwani Katherine,Brouner Krissy,Tung Herman,Casper Tamara,Davoudian Pasha,Sulc Josef,Radaelli Cristina,Wakeman Wayne,Crichton Kirsten,Esposito Luke,Keene C. Dirk.Connectivity and Synaptic Physiology in the Mouse and Human Neocortex[EB/OL].(2025-03-28)[2025-06-05].https://www.biorxiv.org/content/10.1101/2021.03.31.437553.点此复制
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