Two stochastic processes shape diverse senescence patterns in a single-cell organism
Two stochastic processes shape diverse senescence patterns in a single-cell organism
Abstract Despite advances in aging research, basic understanding is lacking of the biological processes that shape senescence. We show that for a isogenic Escherichia coli bacterial population senescence results from two stochastic processes. A primary random deterioration process within the cell, such as generated by random accumulation of damage, leads to an exponential increase in mortality early in life followed by a late age mortality plateau; a secondary process of stochastic asymmetric transmission of an unknown factor at cell fission influences mortality. This second process is required to explain the difference between the classical mortality plateaus detected for young mothers offspring and the near nonsenescence of old mothers’ offspring as well as the lack of a mother offspring correlation in age at death. We observed that life span is predominantly determined by underlying stochastic stage dynamics. Our findings support models based on stage-specific actions of alleles for the evolution of senescence.
Ni Ming、Chen Peipei、Song Xiaohu、Vaupel James W.、Steiner Ulrich K.、Lenart Adam、Taddei Fran?ois、Lindner Ariel B.
Center for Research and Interdisciplinarity, Paris Descartes University||INSERM U1001||BGI ShenzhenCenter for Research and Interdisciplinarity, Paris Descartes University||National Center for Nanoscience and TechnologyCenter for Research and Interdisciplinarity, Paris Descartes UniversityMax-Planck Odense Centre on the Biodemography of AgingMax-Planck Odense Centre on the Biodemography of Aging||Biology Department, University of Southern Denmark||Center for Research and Interdisciplinarity, Paris Descartes University||INSERM U1001Max-Planck Odense Centre on the Biodemography of AgingCenter for Research and Interdisciplinarity, Paris Descartes University||INSERM U1001Center for Research and Interdisciplinarity, Paris Descartes University||INSERM U1001
细胞生物学遗传学分子生物学
Ni Ming,Chen Peipei,Song Xiaohu,Vaupel James W.,Steiner Ulrich K.,Lenart Adam,Taddei Fran?ois,Lindner Ariel B..Two stochastic processes shape diverse senescence patterns in a single-cell organism[EB/OL].(2025-03-28)[2025-04-27].https://www.biorxiv.org/content/10.1101/105387.点此复制
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