Population genomics of ancient and modern Trichuris trichiura
Population genomics of ancient and modern Trichuris trichiura
Abstract The neglected tropical disease trichuriasis is caused by the whipworm Trichuris trichiura, a soil-transmitted helminth that has infected humans for millennia. Today, T. trichiura infects as many as 500 million people, predominantly in communities with poor sanitary infrastructure enabling sustained faecal-oral transmission. Using whole-genome sequencing of geographically distributed worms collected from human and other primate hosts, together with ancient samples preserved in archaeologically-defined latrines and deposits dated up to one thousand years old, we present the first population genomics study of T. trichiura. We describe the continent-scale genetic structure between whipworms infecting humans and baboons relative to those infecting other primates. Admixture and population demographic analyses support a stepwise distribution of genetic variation that is highest in Uganda, consistent with an African origin and subsequent translocation with human migration. Finally, genome-wide analyses between human samples and between human and non-human primate samples reveal local regions of genetic differentiation between geographically distinct populations. These data provide insight into zoonotic reservoirs of human-infective T. trichiura and will support future efforts toward the implementation of genomic epidemiology of this globally important helminth.
Nejsum Peter、Betson Martha、Zhu Xing-Quan、Cutillas Cristina、Levecke Bruno、Fredensborg Brian Lund、Outzen Kapel Christian Moliin、S?e Martin Jensen、Mekonnen Zeleke、Tchuent¨| Louis-Albert Tchuem、Namwanje Harriet、Peng Lifei、Fontecha Sandoval Gustavo Adolfo、Matamoros Gabriela、Doyle Stephen R.、Cooper Philip J.、Ame Shaali M.、Berriman Matthew、Sanchez Ana
Department of Clinical Medicine, Aarhus UniversitySchool of Veterinary Medicine, University of SurreyCollege of Veterinary Medicine, Shanxi Agricultural UniversityDepartamento de Microbiolog¨aa y Parasitolog¨aa, Facultad de Farmacia, Universidad de SevillaDepartment of Translational Physiology, Infectiology and Public Health, Ghent UniversityDepartment of Plant and Environmental Sciences, University of CopenhagenDepartment of Plant and Environmental Sciences, University of CopenhagenDepartment of Plant and Environmental Sciences, University of CopenhagenInstitute of Health, School of Medical Laboratory Sciences, Jimma UniversityFaculty of Sciences, University of Yaound¨| IVector Control Division, Ministry of HealthDepartment of Parasitology, School of Basic Medical Sciences, Guangdong Medical UniversityMicrobiology Research Institute, Ciudad Universitaria, Universidad Nacional Aut¨?noma de HondurasMicrobiology Research Institute, Ciudad Universitaria, Universidad Nacional Aut¨?noma de HondurasWellcome Sanger InstituteInstitute of Infection and Immunity, St George?ˉs University of London||School of Medicine, Universidad Internacional del EcuadorPublic Health Laboratory Ivo de CarneriWellcome Sanger InstituteDepartment of Health Sciences, Brock University
医学研究方法基础医学遗传学
Nejsum Peter,Betson Martha,Zhu Xing-Quan,Cutillas Cristina,Levecke Bruno,Fredensborg Brian Lund,Outzen Kapel Christian Moliin,S?e Martin Jensen,Mekonnen Zeleke,Tchuent¨| Louis-Albert Tchuem,Namwanje Harriet,Peng Lifei,Fontecha Sandoval Gustavo Adolfo,Matamoros Gabriela,Doyle Stephen R.,Cooper Philip J.,Ame Shaali M.,Berriman Matthew,Sanchez Ana.Population genomics of ancient and modern Trichuris trichiura[EB/OL].(2025-03-28)[2025-05-12].https://www.biorxiv.org/content/10.1101/2021.10.21.464505.点此复制
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