Predicting future from past: The genomic basis of recurrent and rapid stickleback evolution
Predicting future from past: The genomic basis of recurrent and rapid stickleback evolution
Abstract Similar forms often evolve repeatedly in nature, raising longstanding questions about the underlying mechanisms. Here we use repeated evolution in sticklebacks to identify a large set of genomic loci that change recurrently during colonization of new freshwater habitats by marine fish. The same loci used repeatedly in extant populations also show rapid allele frequency changes when new freshwater populations are experimentally established from marine ancestors. Dramatic genotypic and phenotypic changes arise within 5-7 years, facilitated by standing genetic variation and linkage between adaptive regions. Both the speed and location of changes can be predicted using empirical observations of recurrence in natural populations or fundamental genomic features like allelic age, recombination rates, density of divergent loci, and overlap with mapped traits. A composite model trained on these stickleback features can also predict the location of key evolutionary loci in Darwin’s finches, suggesting similar features are important for evolution across diverse taxa.
Reid Kerry、Roberts Kingman Garrett A、Vyas Deven N、Heins David C、Absher Devin M、Myers Richard M、Di Palma Federica、Kingsley David M、Brady Shannon D、Bell Michael A、Park Peter J、Kirch Melanie、Milhaven Mark、von Hippel Frank A、Chen Heidi I、Jones Felicity C、Bertino Thomas S、Aguirre Windsor E、Veeramah Krishna R
Department of Ecology and Evolution, Stony Brook UniversityDepartment of Developmental Biology, Stanford University School of MedicineDepartment of Ecology and Evolution, Stony Brook UniversityDepartment of Ecology and Evolutionary Biology, Tulane UniversityHudsonAlpha Institute for BiotechnologyHudsonAlpha Institute for BiotechnologyBroad Institute of MIT and HarvardDepartment of Developmental Biology, Stanford University School of Medicine||Howard Hughes Medical InstituteDepartment of Developmental Biology, Stanford University School of MedicineUniversity of California Museum of Paleontology, University of CaliforniaBiology Department, Farmingdale State CollegeFriedrich Miescher Laboratory of the Max Planck SocietyDepartment of Ecology and Evolution, Stony Brook UniversityDepartment of Biological Sciences, Northern Arizona UniversityDepartment of Developmental Biology, Stanford University School of MedicineFriedrich Miescher Laboratory of the Max Planck SocietyDepartment of Ecology and Evolution, Stony Brook UniversityDepartment of Biological Sciences, DePaul UniversityDepartment of Ecology and Evolution, Stony Brook University
遗传学分子生物学
Reid Kerry,Roberts Kingman Garrett A,Vyas Deven N,Heins David C,Absher Devin M,Myers Richard M,Di Palma Federica,Kingsley David M,Brady Shannon D,Bell Michael A,Park Peter J,Kirch Melanie,Milhaven Mark,von Hippel Frank A,Chen Heidi I,Jones Felicity C,Bertino Thomas S,Aguirre Windsor E,Veeramah Krishna R.Predicting future from past: The genomic basis of recurrent and rapid stickleback evolution[EB/OL].(2025-03-28)[2025-05-01].https://www.biorxiv.org/content/10.1101/2020.11.13.382424.点此复制
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