右美托咪定经鼻给药在临床中的研究进展

exmedetomidine is a hepatically eliminated drug ，as an α2-adrenergic receptor agonist, demedetomidine exerts sedative, analgesic, anti-anxiety, and decrease the incidence of chill without causing respiratory depression by acting on the G-protein-coupled receptor in the brain locus locus locus and the postsynaptic membrane a2 receptor in the posterior horn of the spinal cord through traditional intravenous administration, but it also causes hemodynamic fluctuations. In the special population, this effect may be more prominent. In this review, the research progress of demedetomidine intranasal titration, a new administration method for the elderly population, was reviewed, and its influence on the elderly was explored, in order to provide a new direction, mental thinking and new method for clinical treatment of special population.