Heterogeneous immunological recovery trajectories revealed in post-acute COVID-19
Heterogeneous immunological recovery trajectories revealed in post-acute COVID-19
Abstract The immunological picture of how different patients recover from COVID-19, and how those recovery trajectories are influenced by infection severity, remain unclear. We investigated 140 COVID-19 patients from diagnosis to convalescence using clinical data, viral load assessments, and multi-omic analyses of blood plasma and circulating immune cells. Immune-phenotype dynamics resolved four recovery trajectories. One trajectory signals a return to pre-infection healthy baseline, while the other three are characterized by differing fractions of persistent cytotoxic and proliferative T cells, distinct B cell maturation processes, and memory-like innate immunity. We resolve a small panel of plasma proteins that, when measured at diagnosis, can predict patient survival and recovery-trajectory commitment. Our study offers novel insights into post-acute immunological outcomes of COVID-19 that likely influence long-term adverse sequelae.
the ISB-Swedish COVID19 Biobanking Unit、Li Sarah、Wrin Terri、Wang Kai、Scherler Kelsey、Dong Shen、Fallen Shannon、Kornilov Sergey A.、Baloni Priyanka、Duvvuri Venkata R.、Anderson Kristin G.、Yang Fan、Troisch Pamela、Smith Brett、Algren Heather A、Lee Inyoul、Petropoulos Christos J.、Subramanian Naeha、Ribas Antoni、Boyd Scott D.、Hood Leroy、Yuan Dan、Choi Jongchan、Dai Chengzhen L.、Xie Jingyi、Heath James R.、Rowen Lee、Liu Rachel、Lausted Christopher、Hadlock Jennifer、Berrington William R.、Rostomily Clifford、Magis Andrew T.、Li Jing、Goldman Jason D.、Greenberg Philip D.、Murray Kim、Chour William、Ng Rachel H.、Edmark Rick、Gottardo Raphael、Chen Daniel G.、Davis Mark M.、Price Nathan D.、Bluestone Jeffrey A.、Lanier Lewis L.、Wallick Julie A、Zhou Jing、Zhou Yong、Mackay Sean、Pavlovitch-Bedzyk Ana Jimena、Jones Lesley、Wei Wei、Zhang Rongyu、Hong Sunga、Su Yapeng
Institute for Systems BiologyMonogram Biosciences, South San FranciscoInstitute for Systems BiologyInstitute for Systems BiologyDiabetes Center, University of CaliforniaInstitute for Systems BiologyInstitute for Systems BiologyInstitute for Systems BiologyInstitute for Systems BiologyClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle||Departments of Immunology and Medicine, University of WashingtonDepartment of Pathology, Stanford UniversityInstitute for Systems BiologyInstitute for Systems BiologySwedish Center for Research and Innovation, Swedish Medical Center||Providence St. Joseph HealthInstitute for Systems BiologyMonogram Biosciences, South San FranciscoInstitute for Systems Biology||Department of Global Heath, and Department of Immunology, University of WashingtonDepartment of Medicine, University of California, Los Angeles, and Parker Institute for Cancer ImmunotherapyDepartment of Pathology, Stanford UniversityInstitute for Systems Biology||Providence St. Joseph HealthInstitute for Systems Biology||Department of Bioengineering, University of WashingtonInstitute for Systems BiologyInstitute for Systems BiologyInstitute for Systems BiologyInstitute for Systems Biology||Department of Bioengineering, University of WashingtonInstitute for Systems BiologyInstitute for Systems BiologyInstitute for Systems BiologyInstitute for Systems BiologySwedish Center for Research and Innovation, Swedish Medical Center||Providence St. Joseph HealthInstitute for Systems BiologyInstitute for Systems BiologyInstitute for Immunity, Transplantation and Infection, Stanford University School of MedicineSwedish Center for Research and Innovation, Swedish Medical Center||Providence St. Joseph Health||Division of Allergy & Infectious Diseases, University of WashingtonClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle||Departments of Immunology and Medicine, University of WashingtonInstitute for Systems BiologyInstitute for Systems BiologyInstitute for Systems Biology||Department of Bioengineering, University of WashingtonInstitute for Systems BiologyVaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center||Division of Public Health Sciences, Fred Hutchinson Cancer Research Center||Department of Statistics, University of WashingtonInstitute for Systems BiologyInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine||Department of Microbiology and Immunology, Stanford University School of Medicine||The Howard Hughes Medical Institute, Stanford University School of MedicineInstitute for Systems BiologyDiabetes Center, University of CaliforniaDepartment of Microbiology and Immunology, University of California, San Francisco, and Parker Institute for Cancer ImmunotherapySwedish Center for Research and Innovation, Swedish Medical Center||Providence St. Joseph HealthIsoplexis CorporationInstitute for Systems BiologyIsoplexis CorporationInstitute for Immunity, Transplantation and Infection, Stanford University School of MedicineInstitute for Systems BiologyInstitute for Systems BiologyInstitute for Systems Biology||Department of Bioengineering, University of WashingtonInstitute for Systems BiologyInstitute for Systems Biology||Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center||Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle
医学研究方法基础医学
the ISB-Swedish COVID19 Biobanking Unit,Li Sarah,Wrin Terri,Wang Kai,Scherler Kelsey,Dong Shen,Fallen Shannon,Kornilov Sergey A.,Baloni Priyanka,Duvvuri Venkata R.,Anderson Kristin G.,Yang Fan,Troisch Pamela,Smith Brett,Algren Heather A,Lee Inyoul,Petropoulos Christos J.,Subramanian Naeha,Ribas Antoni,Boyd Scott D.,Hood Leroy,Yuan Dan,Choi Jongchan,Dai Chengzhen L.,Xie Jingyi,Heath James R.,Rowen Lee,Liu Rachel,Lausted Christopher,Hadlock Jennifer,Berrington William R.,Rostomily Clifford,Magis Andrew T.,Li Jing,Goldman Jason D.,Greenberg Philip D.,Murray Kim,Chour William,Ng Rachel H.,Edmark Rick,Gottardo Raphael,Chen Daniel G.,Davis Mark M.,Price Nathan D.,Bluestone Jeffrey A.,Lanier Lewis L.,Wallick Julie A,Zhou Jing,Zhou Yong,Mackay Sean,Pavlovitch-Bedzyk Ana Jimena,Jones Lesley,Wei Wei,Zhang Rongyu,Hong Sunga,Su Yapeng.Heterogeneous immunological recovery trajectories revealed in post-acute COVID-19[EB/OL].(2025-03-28)[2025-08-28].https://www.medrxiv.org/content/10.1101/2021.03.19.21254004.点此复制
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